Document Detail

Four amino acids of an insect densovirus capsid determine midgut tropism and virulence.
MedLine Citation:
PMID:  22379098     Owner:  NLM     Status:  MEDLINE    
Densoviruses are insect parvoviruses that are orally infectious for Lepidoptera. To assess the mechanisms underlying their specificity and their virulence, we investigated the role of eight candidate residues in the densovirus capsid. We showed that the substitutions of four amino acids were associated with decreased virulence due to a decreased ability to cross the host midgut epithelium, without an effect on viral replication in other tissues.
Cecilia Multeau; Rémy Froissart; Aurélie Perrin; Ilaria Castelli; Morena Casartelli; Mylène Ogliastro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-29
Journal Detail:
Title:  Journal of virology     Volume:  86     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-25     Completed Date:  2012-06-18     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5937-41     Citation Subset:  IM    
Invivo AgroSolutions, Valbonne, France.
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MeSH Terms
Amino Acid Motifs
Amino Acid Sequence
Capsid Proteins / chemistry*,  genetics,  metabolism*
Densovirus / chemistry,  genetics,  pathogenicity*,  physiology*
Intestines / virology
Models, Molecular
Molecular Sequence Data
Spodoptera / virology*
Viral Tropism*
Virus Replication
Reg. No./Substance:
0/Capsid Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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