Document Detail


Four-year weight losses in the Look AHEAD study: factors associated with long-term success.
MedLine Citation:
PMID:  21779086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P < 0.0001). More ILI than DSE participants lost ≥ 5% (46% vs. 25%, P < 0.0001) and ≥ 10% (23% vs. 10%, P < 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost ≥ 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.
Authors:
Thomas A Wadden; Rebecca H Neiberg; Rena R Wing; Jeanne M Clark; Linda M Delahanty; James O Hill; Jonathan Krakoff; Amy Otto; Donna H Ryan; Mara Z Vitolins;
Related Documents :
2726146 - The effect of hyaluronidase on akinesia during cataract surgery.
14666036 - Extrapleural regional versus systemic analgesia for relieving postthoracotomy pain: a c...
19920426 - Ultrasound-guided low-dose interscalene brachial plexus block reduces the incidence of ...
3717616 - Comparison of ph-adjusted lidocaine solutions for epidural anesthesia.
9476766 - Endoscopic management of dieulafoy lesions of the stomach: a case study of 26 patients.
7829606 - The long-term outcome after adrenalectomy and prophylactic pituitary radiotherapy in ad...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2011-07-21
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  19     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-28     Completed Date:  2012-03-27     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1987-98     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Diabetes Mellitus, Type 2 / complications*
Diet*
Energy Intake
Exercise*
Female
Group Processes
Health Education*
Humans
Life Style
Male
Middle Aged
Obesity / complications,  therapy*
Treatment Outcome
Weight Loss*
Weight Reduction Programs*
Grant Support
ID/Acronym/Agency:
DK 046204/DK/NIDDK NIH HHS; DK56990/DK/NIDDK NIH HHS; DK56992/DK/NIDDK NIH HHS; DK57002/DK/NIDDK NIH HHS; DK57008/DK/NIDDK NIH HHS; DK57078/DK/NIDDK NIH HHS; DK57131/DK/NIDDK NIH HHS; DK57135/DK/NIDDK NIH HHS; DK57136/DK/NIDDK NIH HHS; DK57149/DK/NIDDK NIH HHS; DK57151/DK/NIDDK NIH HHS; DK57154/DK/NIDDK NIH HHS; DK57171/DK/NIDDK NIH HHS; DK57177/DK/NIDDK NIH HHS; DK57178/DK/NIDDK NIH HHS; DK57182/DK/NIDDK NIH HHS; DK57219/DK/NIDDK NIH HHS; M01RR000056/RR/NCRR NIH HHS; M01RR00051/RR/NCRR NIH HHS; M01RR0021140/RR/NCRR NIH HHS; M01RR01066/RR/NCRR NIH HHS; M01RR01346/RR/NCRR NIH HHS; M01RR02719/RR/NCRR NIH HHS; P30 DK48520/DK/NIDDK NIH HHS; U01 DK057135/DK/NIDDK NIH HHS; U01 DK057135-11/DK/NIDDK NIH HHS; UL1 RR 024153/RR/NCRR NIH HHS
Investigator
Investigator/Affiliation:
Frederick L Brancati / ; Lee Swartz / ; Lawrence Cheskin / ; Jeanne M Clark / ; Kerry Stewart / ; Richard Rubin / ; Jean Arceci / ; Suzanne Bau / ; Jeanne Charleston / ; Danielle Diggins / ; Mia Johnson / ; Joyce Lambert / ; Kathy Michalski / ; Daron Niggetts / ; Chanchai Sapun / ; George A Bray / ; Kristi Rau / ; Allison Strate / ; Frank L Greenway / ; Donna H Ryan / ; Donald Williamson / ; Brandi Armand / ; Jennifer Arceneaux / ; Amy Bachand / ; Michelle Begnaud / ; Betsy Berhard / ; Elizabeth Caderette / ; Barbara Cerniauskas / ; David Creel / ; Crystal Duncan / ; Helen Guay / ; Carolyn Johnson / ; Lisa Jones / ; Nancy Kora / ; Kelly LaFleur / ; Kim Landry / ; Missy Lingle / ; Jennifer Perault / ; Cindy Puckett / ; Mandy Shipp / ; Marisa Smith / ; Elizabeth Tucker / ; Cora E Lewis / ; Sheikilya Thomas / ; Monika Safford / ; Vicki DiLillo / ; Charlotte Bragg / ; Amy Dobelstein / ; Stacey Gilbert / ; Stephen Glasser / ; Sara Hannum / ; Anne Hubbell / ; Jennifer Jones / ; DeLavallade Lee / ; Ruth Luketic / ; L Christie Oden / ; Janet Raines / ; Cathy Roche / ; Janet Truman / ; Nita Webb / ; Casey Azuero / ; Jane King / ; Andre Morgan / ; David M Nathan / ; Enrico Cagliero / ; Kathryn Hayward / ; Heather Turgeon / ; Linda Delahanty / ; Ellen Anderson / ; Laurie Bissett / ; Valerie Goldman / ; Virginia Harlan / ; Theresa Michel / ; Mary Larkin / ; Christine Stevens / ; Kylee Miller / ; Jimmy Chen / ; Karen Blumenthal / ; Gail Winning / ; Rita Tsay / ; Helen Cyr / ; Maria Pinto / ; Edward S Horton / ; Sharon D Jackson / ; Osama Hamdy / ; A Enrique Caballero / ; Sarah Bain / ; Elizabeth Bovaird / ; Barbara Fargnoli / ; Jeanne Spellman / ; Ann Goebel-Fabbri / ; Lori Lambert / ; Sarah Ledbury / ; Maureen Malloy / ; Kerry Ovalle / ; George Blackburn / ; Christos Mantzoros / ; Ann McNamara / ; Kristina Spellman / ; James O Hill / ; Marsha Miller / ; Brent Van Dorsten / ; Judith Regensteiner / ; Ligia Coelho / ; Paulette Cohrs / ; Susan Green / ; April Hamilton / ; Jere Hamilton / ; Eugene Leshchinskiy / ; Lindsey Munkwitz / ; Loretta Rome / ; Terra Worley / ; Kirstie Craul / ; Sheila Smith / ; John P Foreyt / ; Rebecca S Reeves / ; Henry Pownall / ; Ashok Balasubramanyam / ; Peter Jones / ; Michele Burrington / ; Chu-Huang Chen / ; Allyson Clark Gardner / ; Molly Gee / ; Sharon Griggs / ; Michelle Hamilton / ; Veronica Holley / ; Jayne Joseph / ; Julieta Palencia / ; Jennifer Schmidt / ; Carolyn White / ; Karen C Johnson / ; Carolyn Gresham / ; Stephanie Connelly / ; Amy Brewer / ; Mace Coday / ; Lisa Jones / ; Lynne Lichtermann / ; Shirley Vosburg / ; J Lee Taylor / ; Abbas E Kitabchi / ; Ebenezer Nyenwe / ; Helen Lambeth / ; Amy Brewer / ; Debra Clark / ; Andrea Crisler / ; Debra Force / ; Donna Green / ; Robert Kores / ; Robert W Jeffery / ; Carolyn Thorson / ; John P Bantle / ; J Bruce Redmon / ; Richard S Crow / ; Scott Crow / ; Susan K Raatz / ; Kerrin Brelje / ; Carolyne Campbell / ; Jeanne Carls / ; Tara Carmean-Mihm / ; Julia Devonish / ; Emily Finch / ; Anna Fox / ; Elizabeth Hoelscher / ; La Donna James / ; Vicki A Maddy / ; Therese Ockenden / ; Birgitta I Rice / ; Tricia Skarphol / ; Ann D Tucker / ; Mary Susan Voeller / ; Cara Walcheck / ; Xavier Pi-Sunyer / ; Jennifer Patricio / ; Stanley Heshka / ; Carmen Pal / ; Lynn Allen / ; Lolline Chong / ; Marci Gluck / ; Diane Hirsch / ; Mary Anne Holowaty / ; Michelle Horowitz / ; Nancy Rau / ; Dori Brill Steinberg / ; Thomas A Wadden / ; Barbara J Maschak-Carey / ; Robert I Berkowitz / ; Seth Braunstein / ; Gary Foster / ; Henry Glick / ; Shiriki Kumanyika / ; Stanley S Schwartz / ; Michael Allen / ; Yuliis Bell / ; Johanna Brock / ; Susan Brozena / ; Ray Carvajal / ; Helen Chomentowski / ; Canice Crerand / ; Renee Davenport / ; Andrea Diamond / ; Anthony Fabricatore / ; Lee Goldberg / ; Louise Hesson / ; Thomas Hudak / ; Nayyar Iqbal / ; LaShanda Jones-Corneille / ; Andrew Kao / ; Robert Kuehnel / ; Patricia Lipschutz / ; Monica Mullen / ; John M Jakicic / ; David E Kelley / ; Jacqueline Wesche-Thobaben / ; Lewis H Kuller / ; Andrea Kriska / ; Amy D Otto / ; Lin Ewing / ; Mary Korytkowski / ; Daniel Edmundowicz / ; Monica E Yamamoto / ; Rebecca Danchenko / ; Barbara Elnyczky / ; David O Garcia / ; George A Grove / ; Patricia H Harper / ; Susan Harrier / ; Nicole L Helbling / ; Diane Ives / ; Juliet Mancino / ; Anne Mathews / ; Tracey Y Murray / ; Joan R Ritchea / ; Susan Urda / ; Donna L Wolf / ; Rena R Wing / ; Renee Bright / ; Vincent Pera / ; John Jakicic / ; Deborah Tate / ; Amy Gorin / ; Kara Gallagher / ; Amy Bach / ; Barbara Bancroft / ; Anna Bertorelli / ; Richard Carey / ; Tatum Charron / ; Heather Chenot / ; Kimberley Chula-Maguire / ; Pamela Coward / ; Lisa Cronkite / ; Julie Currin / ; Maureen Daly / ; Caitlin Egan / ; Erica Ferguson / ; Linda Foss / ; Jennifer Gauvin / ; Don Kieffer / ; Lauren Lessard / ; Deborah Maier / ; J P Massaro / ; Tammy Monk / ; Rob Nicholson / ; Erin Patterson / ; Suzanne Phelan / ; Hollie Raynor / ; Douglas Raynor / ; Natalie Robinson / ; Deborah Robles / ; Jane Tavares / ; Steven M Haffner / ; Maria G Montez / ; Carlos Lorenzo / ; Charles F Coleman / ; Domingo Granado / ; Kathy Hathaway / ; Juan Carlos Isaac / ; Nora Ramirez / ; Ronda Saenz / ; Steven Kahn / ; Brenda Montgomery / ; Robert Knopp / ; Edward Lipkin / ; Dace Trence / ; Terry Barrett / ; Joli Bartell / ; Diane Greenberg / ; Anne Murillo / ; Betty Ann Richmond / ; Jolanta Socha / ; April Thomas / ; Alan Wesley / ; William C Knowler / ; Paula Bolin / ; Tina Killean / ; Cathy Manus / ; Jonathan Krakoff / ; Jeffrey M Curtis / ; Justin Glass / ; Sara Michaels / ; Peter H Bennett / ; Tina Morgan / ; Shandiin Begay / ; Paul Bloomquist / ; Teddy Costa / ; Bernadita Fallis / ; Jeanette Hermes / ; Diane F Hollowbreast / ; Ruby Johnson / ; Maria Meacham / ; Julie Nelson / ; Carol Percy / ; Patricia Poorthunder / ; Sandra Sangster / ; Nancy Scurlock / ; Leigh A Shovestull / ; Janelia Smiley / ; Katie Toledo / ; Christina Tomchee / ; Darryl Tonemah / ; Anne Peters / ; Valerie Ruelas / ; Siran Ghazarian Sengardi / ; Kathryn Mandy Graves Hillstrom / ; Kati Konersman / ; Sara Serafin-Dokhan / ; Mark A Espeland / ; Judy L Bahnson / ; Lynne E Wagenknecht / ; David Reboussin / ; W Jack Rejeski / ; Alain G Bertoni / ; Wei Lang / ; Michael S Lawlor / ; David Lefkowitz / ; Gary D Miller / ; Patrick S Reynolds / ; Paul M Ribisl / ; Mara Vitolins / ; Haiying Chen / ; Delia S West / ; Lawrence M Friedman / ; Brenda L Craven / ; Kathy M Dotson / ; Amelia Hodges / ; Carrie C Williams / ; Andrea Anderson / ; Jerry M Barnes / ; Mary Barr / ; Daniel P Beavers / ; Tara Beckner / ; Cralen Davis / ; Thania Del Valle-Fagan / ; Patricia A Feeney / ; Candace Goode / ; Jason Griffin / ; Lea Harvin / ; Patricia Hogan / ; Sarah A Gaussoin / ; Mark King / ; Kathy Lane / ; Rebecca H Neiberg / ; Michael P Walkup / ; Karen Wall / ; Terri Windham / ; Michael Nevitt / ; Ann Schwartz / ; John Shepherd / ; Michaela Rahorst / ; Lisa Palermo / ; Susan Ewing / ; Cynthia Hayashi / ; Jason Maeda / ; Santica M Marcovina / ; Jessica Chmielewski / ; Vinod Gaur / ; Elsayed Z Soliman / ; Ronald J Prineas / ; Charles Campbell / ; Zhu-Ming Zhang / ; Teresa Alexander / ; Lisa Keasler / ; Susan Hensley / ; Yabing Li / ; Robert Moran / ; Richard Foushee / ; Nancy J Hall / ; Mary Evans / ; Barbara Harrison / ; Van S Hubbard / ; Susan Z Yanovski / ; Robert Kuczmarski / ; Lawton S Cooper / ; Peter Kaufman / ; Edward W Gregg / ; David F Williamson / ; Ping Zhang /
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Consumer estimation of recommended and actual calories at fast food restaurants.
Next Document:  Brown fat activity is not apparent in subjects with HIV lipodystrophy and increased resting energy e...