| A Four-Dimensional Computed Tomography Analysis of Multiorgan Abdominal Motion. | |
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MedLine Citation:
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PMID: 22197238 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To characterize and quantify multiorgan respiration-induced motion in the abdomen in liver and pancreatic cancer patients. METHODS AND MATERIALS: Four-dimensional computed tomography scans were acquired for 18 patients treated for abdominal tumors. Contours of multiple abdominal organs were drawn by the radiation oncologist at one respiratory phase; these contours were propagated to other respiratory phases by deformable registration. Three-dimensional organ models were generated from the resulting contours at each phase. Motions of the bounding box and center of mass were extracted and analyzed for the clinical target volume and organs at risk. RESULTS: On average, the center of mass motion for liver clinical target volumes was 9.7 mm (SD 5 mm) in the superior-inferior direction, with a range of 3 to 18 mm; for pancreatic tumors, the average was 5 mm (SD 1 mm) m with a range of 3 to 7 mm. Abdominal organs move in unison, but with varying amplitudes. Gating near exhale (T40-T60) reduces the range of motion by a factor of ∼10. CONCLUSION: We have used deformable registration to calculate the trajectories of abdominal organs in four dimensions, based on center of mass and bounding box motion metrics. Our results are compared with previously reported studies. Possible reasons for differences are discussed. |
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Authors:
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Joshua L Hallman; Shinichiro Mori; Gregory C Sharp; Hsiao-Ming Lu; Theodore S Hong; George T Y Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-22 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: - ISSN: 1879-355X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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