Document Detail


Fospropofol.
MedLine Citation:
PMID:  20205488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fospropofol (fospropofol disodium), a sedative/hypnotic agent, is a water-soluble prodrug of propofol, metabolized in vivo to produce liberated propofol (producing the sedative effect), phosphate and formaldehyde. Intravenous fospropofol 6.5 mg/kg was significantly more effective than fospropofol 2.0 mg/kg (a placebo surrogate) as sedation in patients undergoing colonoscopy or flexible bronchoscopy, with regard to the primary endpoint of sedation success rate in randomized, double-blind, phase III trials. In patients undergoing colonoscopy, the sedation success rate was >3-fold higher among fospropofol 6.5 mg/kg (n = 158) than fospropofol 2.0 mg/kg recipients (n = 102). Similar results were observed in patients undergoing flexible bronchoscopy; the sedation success rate was >3-fold greater among fospropofol 6.5 mg/kg (n = 150) than among fospropofol 2.0 mg/kg recipients (n = 102). Fospropofol was generally well tolerated in clinical trials. Adverse events were mostly of mild to moderate severity, and were transient and self-limiting. Patients undergoing flexible bronchoscopy appeared to have a higher rate of sedation-related adverse events requiring airway assistance than did those undergoing colonoscopy or minor procedures.
Authors:
Karly P Garnock-Jones; Lesley J Scott
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  70     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-07-19     Revised Date:  2013-04-16    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  469-77     Citation Subset:  IM    
Affiliation:
Adis, Auckland, New Zealand. demail@adis.co.nz
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Intravenous / administration & dosage,  adverse effects,  pharmacology,  therapeutic use
Bronchoscopy*
Colonoscopy*
Humans
Propofol / administration & dosage,  adverse effects,  analogs & derivatives*,  pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol; LZ257RZP7K/fospropofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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