| Fosphenytoin in infants of extremely low birth weight. | |
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MedLine Citation:
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PMID: 11301224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fosphenytoin, a phosphorylated prodrug of phenytoin, is useful for acute seizures, is given by parenteral administration, and has few cardiac and local irritation adverse effects. There is limited experience in the administration of this new agent to newborns, and concern has been raised regarding the conversion of the prodrug to phenytoin. In two low--birth-weight infants, it was observed that fosphenytoin was converted adequately with varying effects on seizure control. |
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Authors:
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R L Kriel; R F Cifuentes |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 24 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-04-13 Completed Date: 2001-08-23 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 219-21 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, College of Pharmacy, University of Minnesota and Hennepin County Medical Center, Minneapolis, MN 55415, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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administration & dosage,
therapeutic use* Electroencephalography Humans Infant, Newborn Infant, Very Low Birth Weight* Male Phenytoin / administration & dosage, analogs & derivatives, therapeutic use* Seizures / diagnosis, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 57-41-0/Phenytoin; 93390-81-9/fosphenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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