Document Detail

Fosphenytoin in infants of extremely low birth weight.
MedLine Citation:
PMID:  11301224     Owner:  NLM     Status:  MEDLINE    
Fosphenytoin, a phosphorylated prodrug of phenytoin, is useful for acute seizures, is given by parenteral administration, and has few cardiac and local irritation adverse effects. There is limited experience in the administration of this new agent to newborns, and concern has been raised regarding the conversion of the prodrug to phenytoin. In two low--birth-weight infants, it was observed that fosphenytoin was converted adequately with varying effects on seizure control.
R L Kriel; R F Cifuentes
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  24     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-13     Completed Date:  2001-08-23     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-21     Citation Subset:  IM    
Department of Pediatrics, College of Pharmacy, University of Minnesota and Hennepin County Medical Center, Minneapolis, MN 55415, USA.
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MeSH Terms
Anticonvulsants / administration & dosage,  therapeutic use*
Infant, Newborn
Infant, Very Low Birth Weight*
Phenytoin / administration & dosage,  analogs & derivatives,  therapeutic use*
Seizures / diagnosis,  drug therapy*
Reg. No./Substance:
0/Anticonvulsants; 57-41-0/Phenytoin; 93390-81-9/fosphenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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