Document Detail


Fosinopril improves the electrophysiological characteristics of left ventricular hypertrophic myocardium in spontaneously hypertensive rats.
MedLine Citation:
PMID:  25064464     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study investigated the effects of fosinopril on the electrophysiological characteristics of the left ventricular hypertrophic myocardium in spontaneously hypertensive rats (SHRs). Twenty-four 10-week-old male SHRs were divided into fosinopril and non-fosinopril groups (n = 12 each). Twelve 10-week-old Wistar-Kyoto rats were used a control group. Left ventricular mass index and ventricular fibrillation threshold (VFT) were measured after 8 weeks of fosinopril or saline treatment. L-type calcium current (I CaL), sodium current (I Na), and transient outward potassium current (I to) were measured in left ventricular myocytes after 8 weeks of fosinopril or saline treatment using the whole-cell patch-clamp technique. VFT was higher in the fosinopril group than in the non-fosinopril group (17.5 ± 1.2 mA vs. 15.6 ± 1.1 mA, P < 0.01). The density of I CaL was lower in the fosinopril group than in the non-fosinopril group (-7.17 ± 0.13 pA/pF vs. -7.87 ± 0.13 pA/pF, P < 0.05). The density of I to was higher in the fosinopril group than in the non-fosinopril group (14.46 ± 0.28 pA/pF vs. 12.66 ± 0.25 pA/pF, P < 0.05). I to was positively correlated with VFT (r = 0.90, P < 0.001) and was found to be associated independently with VFT (P < 0.001). Fosinopril improves the electrophysiological characteristics of the left ventricular hypertrophic myocardium in SHRs.
Authors:
Zhi-Bin Huang; Chun-Yu Deng; Mao-Huan Lin; Gui-Yi Yuan; Wei Wu
Related Documents :
23291394 - Assessing pre-clinical ventricular dysfunction in obese children and adolescents: the v...
983954 - Vectorcardiographic diagnosis of diaphragmatic myocardial infarction.
23886454 - Prolonged sevoflurane administration in the off-pump coronary artery bypass graft surge...
23050404 - Increased inflammatory response in patients with the first myocardial infarction and no...
21160754 - Stopping the cardiovascular disease continuum: focus on prevention.
11505344 - Impact of off-pump coronary artery surgery on myocardial performance and beta-adrenocep...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-27
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  -     ISSN:  1432-1912     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  TGF? loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
Next Document:  Effect of surface modification by nitrogen ion implantation on the electrochemical and cellular beha...