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Fosfluconazole for antifungal prophylaxis in very low birth weight infants.
MedLine Citation:
PMID:  19946419     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We conducted a retrospective case series study to evaluate the safety of fosfluconazole prophylaxis for preventing invasive fungal infection in VLBW infants with a central vascular access. Fosfluconazole was administered intravenously at a dose of 6 mg/kg everyday during which time a central venous catheter was placed. A total of 23 infants met the criteria for enrollment in our study. No cases of fungal infection were detected during the central venous catheter placement in the group. None of the infants had an elevated beta-D-glucan, and all of them were still alive at discharge. Regarding the liver and renal function, no statistically significant differences were observed before and at the end of fosfluconazole prophylaxis. The results of this study demonstrate that fosfluconazole prophylaxis in preventing invasive fungal infection was well tolerated by VLBW infants. This is a first report to describe antifungal prophylaxis using fosfluconazole for VLBW infants.
Authors:
Daijiro Takahashi; Tomohiko Nakamura; Reiko Shigematsu; Miyu Matsui; Shunsuke Araki; Kazuyasu Kubo; Hiroshi Sato; Akira Shirahata
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Publication Detail:
Type:  Journal Article     Date:  2009-04-23
Journal Detail:
Title:  International journal of pediatrics     Volume:  2009     ISSN:  1687-9759     ISO Abbreviation:  Int J Pediatr     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517077     Medline TA:  Int J Pediatr     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  274768     Citation Subset:  -    
Affiliation:
Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
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