| Foscarnet-induced crystalline glomerulonephritis with nephrotic syndrome and acute renal failure after kidney transplantation. | |
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MedLine Citation:
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PMID: 10360595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Foscarnet nephrotoxicity has been reported to be associated with acute tubulointerstitial nephritis. Crystals in glomerular capillary lumens have also been observed in patients with acquired immunodeficiency syndrome who were treated with foscarnet for cytomegalovirus disease. We describe a kidney transplant recipient who developed a nephrotic syndrome with microscopic hematuria and nonoliguric acute renal failure within 15 days after starting foscarnet therapy for cytomegalovirus infection. A kidney biopsy specimen showed the presence of crystals in all glomeruli and in proximal tubules. Fourier transform infrared microscopy analysis demonstrated that crystals were made from several forms of foscarnet salts: mixed calcium and sodium salts, and unchanged trisodium foscarnet salts. Renal function and proteinuria spontaneously improved, and a second transplant biopsy performed 8 months after the first one revealed fibrotic organization of half of the glomeruli and of interstitial tissue, and crystal vanishing. We were thus able to provide proof of the possible precipitation of foscarnet in a transplanted kidney. |
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Authors:
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G Zanetta; L Maurice-Estepa; C Mousson; E Justrabo; M Daudon; G Rifle; Y Tanter |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Transplantation Volume: 67 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-06-10 Completed Date: 1999-06-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1376-8 Citation Subset: IM; X |
Affiliation:
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Department of Nephrology-Intensive Care, Centre Hospitalier Universitaire, Dijon, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Associated Nephropathy
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chemically induced* Antiviral Agents / adverse effects* Cytomegalovirus Infections / surgery Foscarnet / adverse effects* Glomerulonephritis / chemically induced* Humans Kidney Failure, Acute / complications* Kidney Transplantation* Male Middle Aged Nephrotic Syndrome / complications |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 4428-95-9/Foscarnet |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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