Document Detail

Fos expression in the suprachiasmatic nucleus during photic entrainment of circadian rhythms in retinally damaged rats.
MedLine Citation:
PMID:  14997016     Owner:  NLM     Status:  MEDLINE    
The protein product of the immediate-early gene c-fos is expressed rhythmically in the shell region of the suprachiasmatic nucleus (SCN), the mammalian circadian clock. Recently, we found that exposure to an entraining light pulse caused a suppression of Fos expression in the SCN shell in rats. To study the hypothesis that suppression of Fos in the shell is a correlate of photic entrainment, we used rats that were treated with the retinal neurotoxin monosodium glutamate (MSG) during the neonatal period. In spite of retinal degeneration, MSG-treated rats entrained normally and displayed light-induced suppression of Fos within the SCN shell. These results support the view that light-induced suppression of Fos within the SCN shell is a cellular correlate of photic entrainment.
Christian Beaulé; Jane Barry-Shaw; Shimon Amir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular neuroscience : MN     Volume:  22     ISSN:  0895-8696     ISO Abbreviation:  J. Mol. Neurosci.     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-03     Completed Date:  2004-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002991     Medline TA:  J Mol Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-30     Citation Subset:  IM    
Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada.
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MeSH Terms
Animals, Newborn
Circadian Rhythm / physiology,  radiation effects*
Down-Regulation / physiology,  radiation effects
Photic Stimulation / methods
Proto-Oncogene Proteins c-fos / metabolism*
Rats, Wistar
Receptor, Nerve Growth Factor
Receptors, Nerve Growth Factor / metabolism
Retina / drug effects,  physiology*
Retinal Degeneration / chemically induced,  physiopathology
Sodium Glutamate
Suprachiasmatic Nucleus / cytology,  metabolism*
Up-Regulation / physiology,  radiation effects
Visual Pathways / physiology*
Reg. No./Substance:
0/Neurotoxins; 0/Proto-Oncogene Proteins c-fos; 0/Receptor, Nerve Growth Factor; 0/Receptors, Nerve Growth Factor; 142-47-2/Sodium Glutamate

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