| Forty years of amino acid transmission in the brain. | |
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MedLine Citation:
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PMID: 10482347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article is concerned with the discovery that amino acids, particularly L-glutamate and gamma-aminobutyrate (GABA), are central neurotransmitters. The crucial observations that lead to the conclusion that these two amino acids produce most of the synaptic excitation and inhibition in the central nervous system, were made in late 1950's. The combination of neurochemical knowledge and improved electrophysiological techniques was paramount in making these discoveries possible. In particular, the use of specific antagonists in microiontophoretic experiments provided the most decisive evidence. The relationship is also explored between these early findings and those of the present era characterised by extensive use of techniques of molecular biology and the development of drugs against targets identified 30 to 40 years ago. |
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Authors:
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M R Bennett; V J Balcar |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neurochemistry international Volume: 35 ISSN: 0197-0186 ISO Abbreviation: Neurochem. Int. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-10-18 Completed Date: 1999-10-18 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 269-80 Citation Subset: IM |
Affiliation:
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The Institute for Biomedical Research, The University of Sydney, NSW, Australia. maxb@physiol.usyd.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Brain / metabolism* Neurotransmitter Agents / metabolism* Receptors, Amino Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Neurotransmitter Agents; 0/Receptors, Amino Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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