Document Detail

Fortified complementary foods with or without alpha-amylase treatment increase hemoglobin but do not reduce breast milk intake of 9-mo-old Zambian infants.
MedLine Citation:
PMID:  17921388     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Malnutrition in late infancy in developing countries may result from poor-quality complementary foods that displace breast milk.
OBJECTIVE: The objective of the study was to assess the effects of fortified complementary blends of different energy densities on growth, hemoglobin concentrations, and breast milk intake of 9-mo-old Zambian infants.
DESIGN: Infants were randomly assigned at 6 mo of age to receive for 3 mo a fortified blend of maize, beans, bambaranuts, and groundnuts [Chilenje Baby Mix (CBM); energy density: 68 kcal/100 g; n = 37] or a similar blend with alpha-amylase (CBMA; energy density: 106 kcal/100 g; n = 44). Cross-sectional data were obtained at 9 mo for a control group of infants (n = 69) not given the diets. Breast milk intake was measured by using the dose-to-the-mother deuterium dilution technique.
RESULTS: No differences in weight or length z scores, all of which were within normal ranges, were seen between groups at 9 mo. Percentage fat mass was significantly (P = 0.01) greater in the infants in both the CBM (23.2 +/- 2.7%) and CBMA (23.4 +/- 2.5%) groups than in the control group (21.6 +/- 2.6%). Hemoglobin concentrations were significantly (P = 0.03) greater in both intervention groups (CBM group: 104 +/- 12 g/L: CBMA group: 103 +/- 12 g/L) than in the control group (98 +/- 14 g/L). Breast milk intake was not significantly (P = 0.87) different between groups (CBM group: 614 +/- 271 g/d; CBMA group: 635 +/- 193 g/d; control group: 653 +/- 221 g/d).
CONCLUSIONS: The study foods improved hemoglobin concentrations without reducing breast milk intake and may be used to improve the nutritional status of infants in developing countries.
Victor O Owino; Lackson M Kasonka; Moses M Sinkala; Jonathan K Wells; Simon Eaton; Tegan Darch; Andrew Coward; Andrew M Tomkins; Suzanne M Filteau
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  86     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-08     Completed Date:  2007-11-29     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1094-103     Citation Subset:  AIM; IM    
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MeSH Terms
Adipose Tissue / metabolism
Body Composition
Body Height / drug effects,  physiology
Body Weight / drug effects,  physiology
Cross-Sectional Studies
Eating / drug effects,  physiology
Energy Intake / physiology
Food, Fortified*
Hemoglobins / metabolism*
Infant Food / standards*
Infant Nutritional Physiological Phenomena / drug effects,  physiology*
Micronutrients / administration & dosage*,  metabolism
Milk, Human / chemistry
Nutritional Status
Nutritive Value
alpha-Amylases / administration & dosage*,  metabolism
Grant Support
MC_U105960396//Medical Research Council
Reg. No./Substance:
0/Hemoglobins; 0/Micronutrients; AR09D82C7G/Deuterium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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