| Forskolin perturbs cGMP as well as cAMP levels in human thyroid cells. | |
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MedLine Citation:
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PMID: 6208736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forskolin, at 10(-11) M, stimulates guanylate cyclase activity in primary human thyroid cell cultures, but does not modify cAMP accumulation. At a 10-fold higher concentration it still stimulates guanylate cyclase activity and becomes an inhibitor of cAMP production. Above 10(-9) M, forskolin stimulation of cGMP decreases, while it also becomes a stimulator of cAMP production. There is an additive effect of TSH and forskolin on cAMP production at concentrations of the diterpene which are stimulatory. Concentrations of forskolin which are inhibitory for cAMP, but stimulatory for cGMP, are inhibitory for TSH stimulation of cAMP. The addition of 8-bromo-cGMP duplicates the forskolin effect at low concentrations. |
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Authors:
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M L Brandi; C M Rotella; A Lopponi; L D Kohn; S M Aloj; R Toccafondi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta endocrinologica Volume: 107 ISSN: 0001-5598 ISO Abbreviation: Acta Endocrinol. Publication Date: 1984 Oct |
Date Detail:
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Created Date: 1984-11-27 Completed Date: 1984-11-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370312 Medline TA: Acta Endocrinol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 225-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-3-isobutylxanthine
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pharmacology Cells, Cultured Cyclic AMP / metabolism* Cyclic GMP / analogs & derivatives, metabolism*, pharmacology Diterpenes / pharmacology* Forskolin Humans Phosphodiesterase Inhibitors / pharmacology Thyroid Gland / metabolism* Thyrotropin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Diterpenes; 0/Phosphodiesterase Inhibitors; 28822-58-4/1-Methyl-3-isobutylxanthine; 31356-94-2/8-bromocyclic GMP; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; 7665-99-8/Cyclic GMP; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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