Document Detail


Forskolin perturbs cGMP as well as cAMP levels in human thyroid cells.
MedLine Citation:
PMID:  6208736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forskolin, at 10(-11) M, stimulates guanylate cyclase activity in primary human thyroid cell cultures, but does not modify cAMP accumulation. At a 10-fold higher concentration it still stimulates guanylate cyclase activity and becomes an inhibitor of cAMP production. Above 10(-9) M, forskolin stimulation of cGMP decreases, while it also becomes a stimulator of cAMP production. There is an additive effect of TSH and forskolin on cAMP production at concentrations of the diterpene which are stimulatory. Concentrations of forskolin which are inhibitory for cAMP, but stimulatory for cGMP, are inhibitory for TSH stimulation of cAMP. The addition of 8-bromo-cGMP duplicates the forskolin effect at low concentrations.
Authors:
M L Brandi; C M Rotella; A Lopponi; L D Kohn; S M Aloj; R Toccafondi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  107     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-11-27     Completed Date:  1984-11-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  225-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-3-isobutylxanthine / pharmacology
Cells, Cultured
Cyclic AMP / metabolism*
Cyclic GMP / analogs & derivatives,  metabolism*,  pharmacology
Diterpenes / pharmacology*
Forskolin
Humans
Phosphodiesterase Inhibitors / pharmacology
Thyroid Gland / metabolism*
Thyrotropin / pharmacology
Chemical
Reg. No./Substance:
0/Diterpenes; 0/Phosphodiesterase Inhibitors; 28822-58-4/1-Methyl-3-isobutylxanthine; 31356-94-2/8-bromocyclic GMP; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; 7665-99-8/Cyclic GMP; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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