Document Detail

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian.
MedLine Citation:
PMID:  19865069     Owner:  NLM     Status:  MEDLINE    
Dietary supplements are widely used for desired effects on memory, insomnia, mood and anxiety. This review focuses on supplements which have anxiolytic or mild relaxation properties and enhance mood. For example, Kava (Piper methysticum) is reported to have anaxiolytic actions and to reduce tension through skeletal muscle relaxation. Dried passion flower (genus Passiflora) is reported to reduce insomnia and hysteria. Skullcap (genus Scutellaria), hops (Humulus lupulus), lemon balm (Melissa officinalis) and Valerian (Valeriana officinalis) root are all herbs reported as anaxiolytic calming agents. Further, extracts of Magnolia and Phellondendron bark are mild sedatives. Supplements such as gamma-aminobutyric acid (GABA), theanine, tryptophan and 5-hydroxytryptophan (5-HTP) are reported to promote relaxation. In general, these supplements appear to act as GABA receptor agonists or to boost GABA levels, although Kava inhibits both norephinephrine uptake and sodium and potassium channels and 5-HTP may act through elevation of serotonin. While questions remain in the literature regarding the medicinal value of these supplements in treating mood and anxiety disorders, based on cellular and animal studies as well as human clinical trials the literature supports a role for these preparations as useful alternatives in the management of the stress and anxiety of everyday life.
Benjamin S Weeks
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  15     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-29     Completed Date:  2010-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  RA256-62     Citation Subset:  IM    
Department of Biology, Adelphi University, Garden City, NY 11530, USA.
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MeSH Terms
5-Hydroxytryptophan / pharmacology,  therapeutic use*
Anti-Anxiety Agents / pharmacology,  therapeutic use*
Anxiety / drug therapy*,  physiopathology
Dietary Supplements*
Drug Combinations
Drug Compounding
Glutamates / pharmacology,  therapeutic use*
Plant Extracts / pharmacology,  therapeutic use*
Relaxation / physiology*
gamma-Aminobutyric Acid / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Drug Combinations; 0/Glutamates; 0/Plant Extracts; 0/relarian; 56-12-2/gamma-Aminobutyric Acid; 56-69-9/5-Hydroxytryptophan
Comment In:
Med Sci Monit. 2009 Dec;15(12):LE9   [PMID:  19946249 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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