Document Detail

Formulation of sustained-release verapamil HCl and diltiazem HCl semisolid matrix capsules.
MedLine Citation:
PMID:  18379903     Owner:  NLM     Status:  MEDLINE    
Semisolid matrix capsule formulations of verapamil HCl and diltiazem HCl prepared by hot-melt capsule filling are an especially appealing and simple way to make sustained-release formulations. Semisolid matrices of Gelucire 50/13 and stearic acid combination eroded and disintegrated at various rates, depending on the combination of waxes, and drug release rates were dependent on storage time (2.5 years) and temperature. Semisolid matrices of combinations of only Gelucire 50/13 and cetyl alcohol eroded at a rate much less than combinations of Gelucire 50/13 and stearic acid. The drug release mechanism from Gelucire 50/13: stearic acid matrices involved diffusion and erosion, whereas Gelucire 50/13 and cetyl alcohol matrices exhibited a diffusion mechanism only. A combination of Gelucire 50/13 with cetyl alcohol is more effective than stearic acid in appropriately extending verapamil HCl release from semisolid matrix capsules. The semisolid matrix formulations studied are sensitive to dissolution stirring speeds.
Chien N Nguyen; J Mark Christensen; James W Ayres
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  13     ISSN:  1083-7450     ISO Abbreviation:  Pharm Dev Technol     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-25     Citation Subset:  IM    
Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA.
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MeSH Terms
Chemistry, Pharmaceutical
Delayed-Action Preparations
Diltiazem / administration & dosage,  chemistry*
Verapamil / administration & dosage,  chemistry*
Reg. No./Substance:
0/Capsules; 0/Delayed-Action Preparations; 42399-41-7/Diltiazem; 52-53-9/Verapamil

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