Document Detail

Formulation optimization of an indomethacin-containing photocrosslinked polyacrylic acid hydrogel as an anti-inflammatory patch.
MedLine Citation:
PMID:  18800247     Owner:  NLM     Status:  MEDLINE    
Photocrosslinked polyacrylic acid hydrogel, made from polyacrylic acid (PAA) modified with 2-hydroxyethyl methacrylate (HEMA), is a promising candidate adhesive for dermatological patches. In this study, we investigated the further availability of hydrogel as an adhesive for dermatological patches using a hydrogel containing indomethacin (IDM) as a model anti-inflammatory patch. From an orthogonal experimental study, we clarified the relationships between formulation factors and characteristics of model formulation. Formulations with a lower degree of swelling were prepared by increasing the degree of HEMA modification and the addition of Tween 80. Apparent permeation rate was increased by addition of L-menthol and Tween 80. A tendency for higher HEMA modification to be accompanied by the prolongation of the lag time of IDM was observed. To obtain an applicable anti-inflammatory patch, we conducted a formulation optimization study using a novel optimization method, a response-surface method incorporating multivariate spline interpolation (RSM-S). Consequently, a highly functional anti-inflammatory patch in terms of its adhesive properties and bioavailability was successfully obtained. Since a wide range of functions can be fully controlled by manipulating the formulation factors, photocrosslinked polyacrylic acid hydrogel is an attractive candidate adhesive for dermatological patches.
Masato Nishikawa; Yoshinori Onuki; Koichi Isowa; Kozo Takayama
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-09-18
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  9     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-27     Completed Date:  2009-05-13     Revised Date:  2011-07-27    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1038-45     Citation Subset:  IM    
Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa, Tokyo, 142-8501, Japan.
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MeSH Terms
Acrylic Resins / administration & dosage*,  chemistry,  radiation effects
Administration, Cutaneous
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*,  chemistry,  radiation effects
Chemistry, Pharmaceutical
Cross-Linking Reagents / administration & dosage*,  chemistry,  radiation effects
Hydrogels / administration & dosage*,  chemistry,  radiation effects
Indomethacin / administration & dosage*,  chemistry,  radiation effects
Skin / drug effects,  metabolism
Ultraviolet Rays*
Reg. No./Substance:
0/Acrylic Resins; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cross-Linking Reagents; 0/Hydrogels; 53-86-1/Indomethacin; 9003-01-4/carbopol 940

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