|Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.|
|PMID: 21103342 Owner: NLM Status: MEDLINE|
|BACKGROUND: Dietary supplements have been extensively studied for their beneficial effects on cognition and AD neuropathology. The current study examines the effect of a medical food cocktail consisting of the dietary supplements curcumin, piperine, epigallocatechin gallate, α-lipoic acid, N-acetylcysteine, B vitamins, vitamin C, and folate on cognitive functioning and the AD hallmark features and amyloid-beta (Aβ) in the Tg2576 mouse model of the disease.
PRINCIPAL FINDINGS: The study found that administering the medical food cocktail for 6 months improved cortical- and hippocampal- dependent learning in the transgenic mice, rendering their performance indistinguishable from non-transgenic controls. Coinciding with this improvement in learning and memory, we found that treatment resulted in decreased soluble Aβ, including Aβ oligomers, previously found to be linked to cognitive functioning.
CONCLUSION: In conclusion, the current study demonstrates that combination diet consisting of natural dietary supplements improves cognitive functioning while decreasing AD neuropathology and may thus represent a safe, natural treatment for AD.
|Anna Parachikova; Kim N Green; Curt Hendrix; Frank M LaFerla|
|Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-11-17|
|Title: PloS one Volume: 5 ISSN: 1932-6203 ISO Abbreviation: PLoS ONE Publication Date: 2010|
|Created Date: 2010-11-24 Completed Date: 2011-04-27 Revised Date: 2013-07-03|
Medline Journal Info:
|Nlm Unique ID: 101285081 Medline TA: PLoS One Country: United States|
|Languages: eng Pagination: e14015 Citation Subset: IM|
|Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America.|
|APA/MLA Format Download EndNote Download BibTex|
administration & dosage
Alkaloids / administration & dosage
Alzheimer Disease / drug therapy, genetics, physiopathology*
Amyloid beta-Protein Precursor / genetics, metabolism
Ascorbic Acid / administration & dosage
Benzodioxoles / administration & dosage
Brain / drug effects, pathology, physiopathology*
Catechin / administration & dosage, analogs & derivatives
Cerebral Cortex / drug effects, pathology, physiopathology
Cognition / drug effects, physiology*
Curcumin / administration & dosage
Folic Acid / administration & dosage
Hippocampus / drug effects, pathology, physiopathology
Maze Learning / drug effects
Memory / drug effects
Mice, Inbred C57BL
Mice, Inbred Strains
Piperidines / administration & dosage
Polyunsaturated Alkamides / administration & dosage
Thioctic Acid / administration & dosage
Vitamin B Complex / administration & dosage
Vitamins / administration & dosage
|AG-021982/AG/NIA NIH HHS|
|0/Alkaloids; 0/Amyloid beta-Protein Precursor; 0/Benzodioxoles; 0/Piperidines; 0/Polyunsaturated Alkamides; 0/Vitamins; 12001-76-2/Vitamin B Complex; 154-23-4/Catechin; 458-37-7/Curcumin; 50-81-7/Ascorbic Acid; 59-30-3/Folic Acid; 616-91-1/Acetylcysteine; 62-46-4/Thioctic Acid; BQM438CTEL/epigallocatechin gallate; U71XL721QK/piperine|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dynamic, large-scale profiling of transcription factor activity from live cells in 3D culture.
Next Document: PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during geno...