Document Detail


Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.
MedLine Citation:
PMID:  21103342     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Dietary supplements have been extensively studied for their beneficial effects on cognition and AD neuropathology. The current study examines the effect of a medical food cocktail consisting of the dietary supplements curcumin, piperine, epigallocatechin gallate, α-lipoic acid, N-acetylcysteine, B vitamins, vitamin C, and folate on cognitive functioning and the AD hallmark features and amyloid-beta (Aβ) in the Tg2576 mouse model of the disease.
PRINCIPAL FINDINGS: The study found that administering the medical food cocktail for 6 months improved cortical- and hippocampal- dependent learning in the transgenic mice, rendering their performance indistinguishable from non-transgenic controls. Coinciding with this improvement in learning and memory, we found that treatment resulted in decreased soluble Aβ, including Aβ oligomers, previously found to be linked to cognitive functioning.
CONCLUSION: In conclusion, the current study demonstrates that combination diet consisting of natural dietary supplements improves cognitive functioning while decreasing AD neuropathology and may thus represent a safe, natural treatment for AD.
Authors:
Anna Parachikova; Kim N Green; Curt Hendrix; Frank M LaFerla
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-11-17
Journal Detail:
Title:  PloS one     Volume:  5     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-04-27     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e14015     Citation Subset:  IM    
Affiliation:
Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America.
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / administration & dosage
Alkaloids / administration & dosage
Alzheimer Disease / drug therapy,  genetics,  physiopathology*
Amyloid beta-Protein Precursor / genetics,  metabolism
Animals
Ascorbic Acid / administration & dosage
Benzodioxoles / administration & dosage
Brain / drug effects,  pathology,  physiopathology*
Catechin / administration & dosage,  analogs & derivatives
Cerebral Cortex / drug effects,  pathology,  physiopathology
Cognition / drug effects,  physiology*
Curcumin / administration & dosage
Dietary Supplements*
Folic Acid / administration & dosage
Hippocampus / drug effects,  pathology,  physiopathology
Humans
Immunoblotting
Maze Learning / drug effects
Memory / drug effects
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Mice, Transgenic
Piperidines / administration & dosage
Polyunsaturated Alkamides / administration & dosage
Thioctic Acid / administration & dosage
Vitamin B Complex / administration & dosage
Vitamins / administration & dosage
Grant Support
ID/Acronym/Agency:
AG-021982/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Amyloid beta-Protein Precursor; 0/Benzodioxoles; 0/Piperidines; 0/Polyunsaturated Alkamides; 0/Vitamins; 12001-76-2/Vitamin B Complex; 154-23-4/Catechin; 458-37-7/Curcumin; 50-81-7/Ascorbic Acid; 59-30-3/Folic Acid; 616-91-1/Acetylcysteine; 62-46-4/Thioctic Acid; BQM438CTEL/epigallocatechin gallate; U71XL721QK/piperine
Comments/Corrections

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