| Formulation and in-vitro characterization of retinoic acid loaded poly (lactic-co-glycolic acid) microspheres. | |
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MedLine Citation:
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PMID: 16423759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly (lactic-co-glycolic acid) (PLGA) microspheres containing all-trans retinoic acid (atRA) were prepared by emulsion/solvent evaporation technique. PLGA (50:50) with inherent viscosities of 0.17 and 0.39 dL g(-1) was used. Polyvinyl alcohol (PVA) or PVA and sodium oleate (SO) combinations (4:1) were used to stabilize the emulsions. The effect of polymer viscosity, emulsifier type and concentration on the in vitro release of atRA from the microspheres was investigated. The stability of the microparticles was also tested at the temperatures of 4, 25 and 40 degrees C. The particle size ranged between 1-2 microm. Microspheres were smooth and spherical in shape, as determined by scanning electron microscope (SEM) photographs. The yield of microspheres ranged from 50-75% and the encapsulation efficiency was determined between 45-75%. In vitro release studies showed that atRA release from microspheres lasted for 11 days. |
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Authors:
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Yasemin Cirpanli; Nurşen Unlü; Sema Caliş; A Atilla Hincal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of microencapsulation Volume: 22 ISSN: 0265-2048 ISO Abbreviation: J Microencapsul Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-01-20 Completed Date: 2006-08-21 Revised Date: 2009-07-21 |
Medline Journal Info:
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Nlm Unique ID: 8500513 Medline TA: J Microencapsul Country: England |
Other Details:
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Languages: eng Pagination: 877-89 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents* Biocompatible Materials Delayed-Action Preparations Drug Compounding / methods Drug Stability Emulsifying Agents / pharmacology Lactic Acid* Microscopy, Electron, Scanning / methods Microspheres* Particle Size Polyglycolic Acid* Polymers* Polyvinyl Alcohol Surface Properties Temperature Tretinoin* Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Biocompatible Materials; 0/Delayed-Action Preparations; 0/Emulsifying Agents; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 302-79-4/Tretinoin; 50-21-5/Lactic Acid; 9002-89-5/Polyvinyl Alcohol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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