Document Detail


Formulation and evaluation of carnosic acid nanoparticulate system for upregulation of neurotrophins in the brain upon intranasal administration.
MedLine Citation:
PMID:  23020597     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To develop formulations of carnosic acid nanoparticles and to assess their in vivo efficacy to enhance the expression of neurotrophins in rat model. Carnosic acid loaded chitosan nanoparticles were prepared by ionotropic gelation technique using central composite design. Response surface methodology was used to assess the effect of three factors namely chitosan concentration (0.1-1% w/v), tri-poly phosphate concentration (0.1-1% w/v) and sonication time (2-10 min) on the response variables such as particle size, zeta potential, drug encapsulation efficiency and drug release. The neurotrophins level in the rat brain upon intranasal administration of optimized batch of carnosic acid nanoparticles was determined. The experimental values for the formulation were in good agreement with those predicted by the mathematical models. A single intranasal administration of the optimized formulation of carnosic acid nanoparticles was sufficient to result in comparable levels of endogenous neurotrophins level in the brain that was almost on par with four, once a day intranasal administration of solution in rats. The results clearly demonstrated the fact that nanoparticulate drug delivery system for intranasal administration of carnosic acid would require less number of administrations to elicit the required pharmacological activity owing to its ability to localize on the olfactory mucosal region and provide controlled delivery of carnosic acid for prolonged time periods.
Authors:
Siva Ram Kiran Vaka; H N Shivakumar; Michael A Repka; S Narasimha Murthy
Related Documents :
9630537 - 1h nmr study of dynamics and thermodynamics of acid-alkaline transition in ferric hemog...
18329167 - Dechlorination of atrazine using zero-valent iron (fe0) under neutral ph conditions.
9669047 - Comparison of the effects of concentration, ph and anion species on astringency and sou...
19641187 - Eosinophil viability is increased by acidic ph in a camp- and gpr65-dependent manner.
6412317 - Release of leukotriene c4 from guinea pig trachea.
9354337 - Identification of amino acid residues that control functional behavior in glur5 and glu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  Journal of drug targeting     Volume:  -     ISSN:  1029-2330     ISO Abbreviation:  J Drug Target     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312476     Medline TA:  J Drug Target     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pharmaceutics, The University of Mississippi School of Pharmacy, University , MS , USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Characterization of Mercury Binding onto a Novel Brominated Biomass Ash Sorbent by X-ray Absorption ...
Next Document:  Antibody-linked spherical nucleic acids for cellular targeting.