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Formulation of diclofenac for dermal delivery.
MedLine Citation:
PMID:  25091375     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Diclofenac (DF) was first synthesized in the 1960's and is currently available as ophthalmic, oral, parenteral, rectal and skin preparations. This review focuses on the administration of DF to the skin. As a member of the non-steroidal anti-inflammatory (NSAID) group of drugs the primary indications of DF are for the management of inflammation and pain but it is also used to treat actinic keratosis. The specific aims of this paper are to (i) Provide an overview of the pharmacokinetics and metabolism of DF following oral and topical administration (ii) Examine critically the various formulation approaches which have been investigated to enhance dermal delivery of DF (iii) Identify new formulation strategies for enhanced DF skin penetration.
Authors:
Choon Fu Goh; Majella E Lane
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-1
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  -     ISSN:  1873-3476     ISO Abbreviation:  Int J Pharm     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier B.V.
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