Document Detail

Formulation development of allopurinol suppositories and injectables.
MedLine Citation:
PMID:  10596359     Owner:  NLM     Status:  MEDLINE    
Allopurinol was formulated into injectable and suppository dosage forms. The injectable formulation was prepared by dissolving allopurinol in a cosolvent system consisting of dimethyl sulfoxide (DMSO) and propylene glycol (v/v = 50/50). The stability of allopurinol in the cosolvent system was studied under accelerated storage conditions, and results indicate first-order degradation kinetics with an activation energy of 24.3 kcal/mol. The development of suppository dosage forms was performed by formulating allopurinol with polyethylene glycol (PEG) mixtures of different molecular weights. In vitro release profiles of suppositories formulated with different polyethylene bases were obtained in the pH 7.4 buffer solution using the USP 23 paddle method at 100 rpm. Results indicate that the release rate of the suppository formulations containing PEG 1500/PEG 4000 at the ratio (w/w) of 2.5/10 to 10/2.5 appeared to be similar. However, the addition of sodium lauryl sulfate in the suppository decreased the release rate of allopurinol significantly. A future study to establish in vitro/in vivo correlation (iv/ivc) is suggested.
D K Lee; D P Wang
Related Documents :
10028149 - Analysis of 77,000 canine uroliths. perspectives from the minnesota urolith center.
8129379 - Application of a novel 1,1'-dimethylferricinium dye for the determination of uric acid ...
7221659 - Acute obstructive uric acid nephropathy after treatment of neoplastic adenopathy.
8318609 - The functional properties of hemoglobin modified with mellitic dianhydride: possible ap...
4979099 - Degradation of uric acid by certain aerobic bacteria.
19021889 - Uric acid deposits in symbiotic marine algae.
22782469 - Quorum sensing inhibition in pseudomonas aeruginosa pao1 by antagonistic compound pheny...
10634489 - High-speed chiral separations on microchip electrophoresis devices.
8319649 - Monitoring genotoxic exposure in uranium miners.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  25     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-11     Completed Date:  2000-01-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1205-8     Citation Subset:  IM    
Department of Pharmacy, Kaoshiung Veterans General Hospital, Kaoshiung, Taiwan, R.O.C.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Allopurinol / administration & dosage*,  chemistry
Antimetabolites, Antineoplastic / administration & dosage*,  chemistry
Chemistry, Physical
Chromatography, High Pressure Liquid
Drug Compounding
Drug Stability
Pharmaceutical Solutions
Physicochemical Phenomena
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 0/Pharmaceutical Solutions; 0/Solvents; 0/Suppositories; 315-30-0/Allopurinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  In vitro conditions for the study of the in vivo performance of sustained-release theophylline matri...
Next Document:  Percutaneous transport of diclofenac sodium from mixtures of fatty alcohol (or fatty acid) and propy...