Document Detail


Formulation and biopharmaceutical evaluation of osmotic matrix tablets of diclofenac sodium.
MedLine Citation:
PMID:  15371108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of our study was to prepare and evaluate osmotic matrix (OM) tablets of diclofenac sodium (DS). In vitro studies were done on USPXXIV dissolution apparatus II in different release medium. Surface characteristics of coating films and osmotic contribution of OM tablets also were studied. In vivo evaluation was carried out in 6 healthy human volunteers using HPLC method to assay plasma samples, and the results were compared with the performance of fabricated matrix and two commercial tablets of DS. Through in vitro drug release kinetics, using regression coefficient analysis and Peppas equation, different pharmacokinetic parameters and relative bioavailability were determined. OM tablets were found to provide more prolonged and controlled therapeutic plasma DS levels and also showed improved bioavailability in comparison to fabricated matrix and commercial tablets studied.
Authors:
Meena Rani; Rahul Surana; C Sankar; B Mishra
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug delivery     Volume:  11     ISSN:  1071-7544     ISO Abbreviation:  Drug Deliv     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-09-16     Completed Date:  2005-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9417471     Medline TA:  Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  263-70     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India. ranix002@umn.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopharmaceutics
Chemistry, Pharmaceutical
Cross-Over Studies
Diclofenac / chemistry*,  pharmacokinetics*
Drug Evaluation / methods
Female
Humans
Male
Osmosis / drug effects
Tablets, Enteric-Coated
Chemical
Reg. No./Substance:
0/Tablets, Enteric-Coated; 15307-86-5/Diclofenac

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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