| Formulation and Optimization of Nanotransfersomes using Experimental Design Technique for Accentuated Transdermal Delivery of Valsartan. | |
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MedLine Citation:
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PMID: 21704600 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of this work was to develop and statistically optimize nanotransfersomes for enhanced transdermal of valsartan vis-à-vis traditional liposomes. Nanotransfersomes bearing valsartan were prepared by conventional rotary evaporation method and characterized for various parameters including entrapment efficiency, vesicles shape, size, size distribution and skin permeation. In vivo antihypertensive activity conducted on wistar rats was also taken as a measure of performance of nanotransfersomes and liposomes. Nanotransfersomes proved significantly superior in terms of, amount of drug permeated in the skin, with an enhancement ratio of 33.97±1.25 when compared to rigid liposomes. This was further confirmed through a confocal laser scanning microscopy study. Nanotransfersomes showed better antihypertensive activity in comparison to liposomes by virtue of better permeation through wistar rat skin. Finally, it could be concluded that the nanotransfersomes accentuates the transdermal flux of valsartan and could be used as a carrier for effective transdermal delivery of valsartan. |
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Authors:
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Abdul Ahad; Mohammed Aqil; Kanchan Kohli; Yasmin Sultana; Mohd Mujeeb; Asgar Ali |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-23 |
Journal Detail:
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Title: Nanomedicine : nanotechnology, biology, and medicine Volume: - ISSN: 1549-9642 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233142 Medline TA: Nanomedicine Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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