Document Detail


Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology: efficient nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries.
MedLine Citation:
PMID:  19463437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The objective of this study was to formulate a nanoparticle (NP)-eluting drug delivery stent system by a cationic electrodeposition coating technology.
BACKGROUND: Nanoparticle-mediated drug delivery systems (DDS) are poised to transform the development of innovative therapeutic devices. Therefore, we hypothesized that a bioabsorbable polymeric NP-eluting stent provides an efficient DDS that shows better and more prolonged delivery compared with dip-coating stent.
METHODS: We prepared cationic NP encapsulated with a fluorescence marker (FITC) by emulsion solvent diffusion method, succeeded to formulate an NP-eluting stent with a novel cation electrodeposition coating technology, and compared the in vitro and in vivo characteristics of the FITC-loaded NP-eluting stent with dip-coated FITC-eluting stent and bare metal stent.
RESULTS: The NP was taken up stably and efficiently by cultured vascular smooth muscle cells in vitro. In a porcine coronary artery model in vivo, substantial FITC fluorescence was observed in neointimal and medial layers of the stented segments that had received the FITC-NP-eluting stent until 4 weeks. In contrast, no substantial FITC fluorescence was observed in the segments from the polymer-based FITC-eluting stent or from bare metal stent. The magnitudes of stent-induced injury, inflammation, endothelial recovery, and neointima formation were comparable between bare metal stent and NP-eluting stent groups.
CONCLUSIONS: Therefore, this NP-eluting stent is an efficient NP-mediated DDS that holds as an innovative platform for the delivery of less invasive nano-devices targeting cardiovascular disease.
Authors:
Kaku Nakano; Kensuke Egashira; Seigo Masuda; Kouta Funakoshi; Gang Zhao; Satoshi Kimura; Tetsuya Matoba; Katsuo Sueishi; Yasuhisa Endo; Yoshiaki Kawashima; Kaori Hara; Hiroyuki Tsujimoto; Ryuji Tominaga; Kenji Sunagawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JACC. Cardiovascular interventions     Volume:  2     ISSN:  1876-7605     ISO Abbreviation:  JACC Cardiovasc Interv     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-08-03     Revised Date:  2012-08-29    
Medline Journal Info:
Nlm Unique ID:  101467004     Medline TA:  JACC Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Absorbable Implants*
Angioplasty, Balloon, Coronary / adverse effects,  instrumentation*
Animals
Cardiovascular Agents / administration & dosage*,  metabolism
Cations
Cells, Cultured
Coated Materials, Biocompatible*
Coronary Restenosis / etiology,  prevention & control
Coronary Vessels / metabolism*,  pathology
Drug-Eluting Stents*
Feasibility Studies
Fluorescein-5-isothiocyanate / metabolism
Fluorescent Dyes / metabolism
Humans
Kinetics
Lactic Acid / chemistry*,  toxicity
Male
Materials Testing
Models, Animal
Muscle, Smooth, Vascular / metabolism
Nanoparticles*
Polyglycolic Acid / chemistry*,  toxicity
Prosthesis Design
Stainless Steel*
Sus scrofa
Chemical
Reg. No./Substance:
0/Cardiovascular Agents; 0/Cations; 0/Coated Materials, Biocompatible; 0/Fluorescent Dyes; 0/polylactic acid-polyglycolic acid copolymer; 12597-68-1/Stainless Steel; 26009-03-0/Polyglycolic Acid; 3326-32-7/Fluorescein-5-isothiocyanate; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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