| Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology: efficient nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries. | |
MedLine Citation:
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PMID: 19463437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The objective of this study was to formulate a nanoparticle (NP)-eluting drug delivery stent system by a cationic electrodeposition coating technology. BACKGROUND: Nanoparticle-mediated drug delivery systems (DDS) are poised to transform the development of innovative therapeutic devices. Therefore, we hypothesized that a bioabsorbable polymeric NP-eluting stent provides an efficient DDS that shows better and more prolonged delivery compared with dip-coating stent. METHODS: We prepared cationic NP encapsulated with a fluorescence marker (FITC) by emulsion solvent diffusion method, succeeded to formulate an NP-eluting stent with a novel cation electrodeposition coating technology, and compared the in vitro and in vivo characteristics of the FITC-loaded NP-eluting stent with dip-coated FITC-eluting stent and bare metal stent. RESULTS: The NP was taken up stably and efficiently by cultured vascular smooth muscle cells in vitro. In a porcine coronary artery model in vivo, substantial FITC fluorescence was observed in neointimal and medial layers of the stented segments that had received the FITC-NP-eluting stent until 4 weeks. In contrast, no substantial FITC fluorescence was observed in the segments from the polymer-based FITC-eluting stent or from bare metal stent. The magnitudes of stent-induced injury, inflammation, endothelial recovery, and neointima formation were comparable between bare metal stent and NP-eluting stent groups. CONCLUSIONS: Therefore, this NP-eluting stent is an efficient NP-mediated DDS that holds as an innovative platform for the delivery of less invasive nano-devices targeting cardiovascular disease. |
Authors:
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Kaku Nakano; Kensuke Egashira; Seigo Masuda; Kouta Funakoshi; Gang Zhao; Satoshi Kimura; Tetsuya Matoba; Katsuo Sueishi; Yasuhisa Endo; Yoshiaki Kawashima; Kaori Hara; Hiroyuki Tsujimoto; Ryuji Tominaga; Kenji Sunagawa |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: JACC. Cardiovascular interventions Volume: 2 ISSN: 1876-7605 ISO Abbreviation: JACC Cardiovasc Interv Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-08-03 Revised Date: 2012-08-29 |
Medline Journal Info:
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Nlm Unique ID: 101467004 Medline TA: JACC Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 277-83 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants* Angioplasty, Balloon, Coronary / adverse effects, instrumentation* Animals Cardiovascular Agents / administration & dosage*, metabolism Cations Cells, Cultured Coated Materials, Biocompatible* Coronary Restenosis / etiology, prevention & control Coronary Vessels / metabolism*, pathology Drug-Eluting Stents* Feasibility Studies Fluorescein-5-isothiocyanate / metabolism Fluorescent Dyes / metabolism Humans Kinetics Lactic Acid / chemistry*, toxicity Male Materials Testing Models, Animal Muscle, Smooth, Vascular / metabolism Nanoparticles* Polyglycolic Acid / chemistry*, toxicity Prosthesis Design Stainless Steel* Sus scrofa |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Cations; 0/Coated Materials, Biocompatible; 0/Fluorescent Dyes; 0/polylactic acid-polyglycolic acid copolymer; 12597-68-1/Stainless Steel; 26009-03-0/Polyglycolic Acid; 3326-32-7/Fluorescein-5-isothiocyanate; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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