|Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology: efficient nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries.|
|PMID: 19463437 Owner: NLM Status: MEDLINE|
|OBJECTIVES: The objective of this study was to formulate a nanoparticle (NP)-eluting drug delivery stent system by a cationic electrodeposition coating technology.
BACKGROUND: Nanoparticle-mediated drug delivery systems (DDS) are poised to transform the development of innovative therapeutic devices. Therefore, we hypothesized that a bioabsorbable polymeric NP-eluting stent provides an efficient DDS that shows better and more prolonged delivery compared with dip-coating stent.
METHODS: We prepared cationic NP encapsulated with a fluorescence marker (FITC) by emulsion solvent diffusion method, succeeded to formulate an NP-eluting stent with a novel cation electrodeposition coating technology, and compared the in vitro and in vivo characteristics of the FITC-loaded NP-eluting stent with dip-coated FITC-eluting stent and bare metal stent.
RESULTS: The NP was taken up stably and efficiently by cultured vascular smooth muscle cells in vitro. In a porcine coronary artery model in vivo, substantial FITC fluorescence was observed in neointimal and medial layers of the stented segments that had received the FITC-NP-eluting stent until 4 weeks. In contrast, no substantial FITC fluorescence was observed in the segments from the polymer-based FITC-eluting stent or from bare metal stent. The magnitudes of stent-induced injury, inflammation, endothelial recovery, and neointima formation were comparable between bare metal stent and NP-eluting stent groups.
CONCLUSIONS: Therefore, this NP-eluting stent is an efficient NP-mediated DDS that holds as an innovative platform for the delivery of less invasive nano-devices targeting cardiovascular disease.
|Kaku Nakano; Kensuke Egashira; Seigo Masuda; Kouta Funakoshi; Gang Zhao; Satoshi Kimura; Tetsuya Matoba; Katsuo Sueishi; Yasuhisa Endo; Yoshiaki Kawashima; Kaori Hara; Hiroyuki Tsujimoto; Ryuji Tominaga; Kenji Sunagawa|
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|Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't|
|Title: JACC. Cardiovascular interventions Volume: 2 ISSN: 1876-7605 ISO Abbreviation: JACC Cardiovasc Interv Publication Date: 2009 Apr|
|Created Date: 2009-05-25 Completed Date: 2009-08-03 Revised Date: 2014-09-05|
Medline Journal Info:
|Nlm Unique ID: 101467004 Medline TA: JACC Cardiovasc Interv Country: United States|
|Languages: eng Pagination: 277-83 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Angioplasty, Balloon, Coronary / adverse effects, instrumentation*
Cardiovascular Agents / administration & dosage*, metabolism
Coated Materials, Biocompatible*
Coronary Restenosis / etiology, prevention & control
Coronary Vessels / metabolism*, pathology
Fluorescein-5-isothiocyanate / metabolism
Fluorescent Dyes / metabolism
Lactic Acid / chemistry*, toxicity
Muscle, Smooth, Vascular / metabolism
Polyglycolic Acid / chemistry*, toxicity
|0/Cardiovascular Agents; 0/Cations; 0/Coated Materials, Biocompatible; 0/Fluorescent Dyes; 0/polylactic acid-polyglycolic acid copolymer; 12597-68-1/Stainless Steel; 26009-03-0/Polyglycolic Acid; 33X04XA5AT/Lactic Acid; I223NX31W9/Fluorescein-5-isothiocyanate|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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