| Formulation of 18F-FDG: pH Adjustment of Buffered Solution. | |
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MedLine Citation:
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PMID: 22279238 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The steam-sterilized (18)F-FDG of our laboratory frequently has a pH of around 6.5. To avoid decomposition, we studied the possibility of adjusting the pH by adding a pharmaceutical compound but without modifying the usual production sequence and reagents. Methods: Citric acid in 4 concentrations (0.01, 0.03, 0.05, and 0.06 M) was added to routine batches of (18)F-FDG. Established pharmacopeia quality controls at 0 and 12 h after synthesis were run, and the dilution effect was checked. RESULTS: A 0.06 M concentration of 1:15 v/v citric acid brought about a pH range of 5.46-5.68; did not change significantly after 1/10 dilution; and did not interfere with quality control. The results of quality control 12 h after dispensing were in the desired range. CONCLUSION: A 0.06 M concentration of 1:15 v/v citric acid modifies pH in a buffered (18)F-FDG solution without the need to change the synthesizer protocol or reagent composition. This new formulation allows pH adjustment; is an easy, reliable, and safe method with no technical difficulties; and does not interfere with the quality of the radiopharmaceutical. |
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Authors:
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Teresa Martinez; Luis Leiva |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Journal of nuclear medicine technology Volume: - ISSN: 1535-5675 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0430303 Medline TA: J Nucl Med Technol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Unidad de Radiofarmacia, Hospital General Universitario Santa Lucía, Cartagena, Murcia, Spain; and. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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