| Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonates. | |
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MedLine Citation:
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PMID: 14523049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infant formulas supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA) are now available in the United States; however, little is known about the factors that affect biosynthesis. Baboon neonates were assigned to one of four treatments: term, breast-fed; term, formula-fed; preterm (155 of 182 days gestation), formula-fed; and preterm, formula+DHA/ARA-fed. Standard formula had no DHA/ARA; supplemented formula had 0.61%wt DHA (0.3% of calories) and 1.21%wt ARA (0.6% of calories), and baboon breast milk contained 0.68 +/- 0.22%wt DHA and 0.62 +/- 0.12%wt ARA. At 14 days adjusted age, neonates received a combined oral dose of [U-13C]alpha-linolenic acid (LNA*) and [U-13C]linoleic acid (LA*), and tissues were analyzed 14 days after dose. Brain accretion of linolenic acid-derived DHA was approximately 3-fold greater for the formula groups than for the breast-fed group, and dietary DHA partially attenuated excess DHA synthesis among preterms. A similar, significant pattern was found in other organs. Brain linoleic acid-derived ARA accretion was significantly greater in the unsupplemented term group but not in the preterm groups compared with the breast-fed group. These data show that formula potentiates the biosynthesis/accretion of DHA/ARA in term and preterm neonates compared with breast-fed neonates and that the inclusion of DHA/ARA in preterm formula partially restores DHA/ARA biosynthesis to lower, breast-fed levels. Current formula DHA concentrations are inadequate to normalize long-chain polyunsaturated fatty acids synthesis to that of breast-fed levels. |
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Authors:
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Eszter Sarkadi-Nagy; Vasuki Wijendran; Guan Yeu Diau; Angela Chueh Chao; Andrea T Hsieh; Anu Turpeinen; Peter Lawrence; Peter W Nathanielsz; J Thomas Brenna |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2003-10-01 |
Journal Detail:
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Title: Journal of lipid research Volume: 45 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-26 Completed Date: 2004-09-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
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Languages: eng Pagination: 71-80 Citation Subset: IM |
Affiliation:
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Division of Nutritional Sciences, Savage Hall, Cornell University, Ithaca, NY 14853. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed* Animals Animals, Newborn / metabolism* Arachidonic Acid / biosynthesis* Body Weight Brain / metabolism Docosahexaenoic Acids / metabolism* Erythrocytes / metabolism Female Gestational Age* Infant Formula / pharmacology* Linear Models Liver / metabolism Male Organ Size Papio / physiology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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EY-10208/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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