| Formula Diet is Effective for the Reduction and Differentiation of Visceral Adipose Tissue in Zucker Fatty Rats. | |
| | |
MedLine Citation:
|
PMID: 22104175 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Aim: Formula diet (FD), which is used as a tool for calorie restriction, has beneficial effects on metabolic disorders in obese patients; however, the molecular mechanism is not fully understood.Methods: Sixteen-week-old male Zucker Diabetic Fatty (ZDF) rats were divided into 3 groups (n= 10 each): calorie-controlled low-fat diet [Control; 75 kcal/day, protein : fat : carbohydrate (P:F:C)=25:15: 60], calorie-restricted low-fat diet (CR-LFD; 56 kcal/day, P:F:C=25:15:60), and calorie-restricted FD (CR-FD; 56 kcal/day, P:F:C=50:14:36) group, and fed each diet for 4 weeks. Before the study, baseline data were obtained in 10 rats. After 4 weeks, body weight and epididymal fat weight were measured, and blood samples, mesenteric and subcutaneous adipose tissues were collected for analyses. Messenger RNA expression was evaluated by real-time PCR, and protein expression by Western blotting.Results: The decrease in epididymal fat weight was significantly greater in the CR-FD group than in control and CR-LFD groups, although changes in body weight were not different among groups. The decrease in fasting plasma glucose and increase in plasma adiponectin were greater in the CR-FD group than in the control group, but not in the CR-LFD group. The decrease in triglyceride and increase in HDL-cholesterol were greatest in the CR-FD group. Both mRNA and protein of peroxisome proliferator-activated receptor γ coactivator (PGC)-1α, adiponectin, lipoprotein lipase and PPARγ were overexpressed in the CR-FD group, especially in mesenteric adipose tissue.Conclusions: FD may have beneficial effects on abdominal obesity and metabolic disorders by reducing visceral fat and improving glucose and lipid profiles, possibly through modulating adipose tissue function.Key words; Formula diet, High protein diet, Low carbohydrate diet, Obesity, Zucker diabetic fatty rat. |
| | |
Authors:
|
Takashi Yamaguchi; Yoh Miyashita; Atsuhito Saiki; Fusako Watanabe; Hitoshi Watanabe; Kohji Shirai |
Related Documents
:
|
8430885 - Effects of weight cycling in rats allowed a choice of diet. 21927895 - Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid o... 17218435 - Modest weight gain is associated with sympathetic neural activation in nonobese humans. 21596155 - High-density lipoprotein remains elevated despite reductions in total cholesterol in fa... 3082575 - Forms of malnutrition in stressed and unstressed patients. 19167915 - Lipid metabolism and hyperlipidemia in dogs. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-21 |
Journal Detail:
|
Title: Journal of atherosclerosis and thrombosis Volume: - ISSN: 1880-3873 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Activation of TGF-? Receptors and Smad Proteins by Atorvastatin is Related to Reduced Atherogenesis ...
Next Document: Plasma Levels of Platelet-Derived Microparticles in Patients with Obstructive Sleep Apnea Syndrome.