Document Detail


Formoterol turbuhaler is as effective as salbutamol diskus in relieving adenosine-induced bronchoconstriction in children.
MedLine Citation:
PMID:  17388747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Salbutamol diskus (SD) and formoterol turbuhaler (FT) are both fast-acting beta(2) agonists delivery systems used to relieve bronchoconstriction, such as that which accompanies acute exacerbations of asthma. Although SD (which is used only on an as-needed basis) is flow independent, the FT (currently recommended for regular therapy) requires a forceful deep inspiration. Thus, the efficacy of FT in children with bronchoconstriction may be inferior to that of SD. We have studied the bronchodilatation response induced by FT after a standard adenosine-5-monophosphate (AMP) bronchial challenge, and compared it to that induced by SD, and placebo. Seventeen children (mean age +/- SD 10.3 +/- 1.7 y) with asthma underwent three AMP challenges, each time followed by inhalation of either placebo, SD (200 mug) or FT (9 mug), in random order. Patterns of bronchodilatation (forced expiratory volume in 1 second recovery) to 90% of baseline levels were compared. Both SD and FT were significantly better than placebo. FT was slightly better than SD, but this difference was not statistically significant. FT and SD are both effective bronchodilators and may be of comparable efficiency during acute bronchoconstriction in young children with asthma.
Authors:
Israel Amirav; Renata Yacobov; Anthony S Luder
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine     Volume:  20     ISSN:  0894-2684     ISO Abbreviation:  J Aerosol Med     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-28     Completed Date:  2007-05-04     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  8809251     Medline TA:  J Aerosol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  T    
Affiliation:
Department of Paediatrics, Sieff Hospital, Safed, Israel. amirav@012.net.il
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MeSH Terms
Descriptor/Qualifier:
Adenosine Monophosphate / diagnostic use*
Administration, Inhalation
Adolescent
Adrenergic beta-Agonists / administration & dosage*
Albuterol / administration & dosage*
Asthma / drug therapy,  physiopathology
Bronchial Provocation Tests*
Bronchoconstriction / drug effects*
Bronchoconstrictor Agents / diagnostic use*
Bronchodilator Agents / administration & dosage*
Child
Dose-Response Relationship, Drug
Ethanolamines / administration & dosage*
Female
Forced Expiratory Volume / drug effects
Humans
Inhalation / physiology
Male
Nebulizers and Vaporizers*
Placebos
Recovery of Function
Spirometry
Time Factors
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Bronchoconstrictor Agents; 0/Bronchodilator Agents; 0/Ethanolamines; 0/Placebos; 18559-94-9/Albuterol; 5ZZ84GCW8B/formoterol; 61-19-8/Adenosine Monophosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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