| Formation and regeneration of the endocrine pancreas. | |
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MedLine Citation:
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PMID: 18061427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The elaboration of the pancreas from epithelial buds to the intricate organ requires complex patterning information that controls fundamental cellular processes such as differentiation and proliferation of pancreatic progenitor cells. During pancreatic organogenesis, endocrine cells are generated from a population of pancreatic progenitor cells. The progenitor cells during the early development simultaneously receive multiple signals, some mitogenic and some inducing differentiation. These extrinsic signals are interpreted through an intrinsic mechanism that either commits the progenitor cell to the mitotic cell cycle or leads to exit from the cell cycle in order to differentiate. The endocrine cells that differentiate from progenitor cells are postmitotic, and direct lineage tracing analyses indicate that a population of progenitor cells persists throughout embryogenesis to allow the differentiation of new endocrine cells. At the end of embryogenesis an early postnatal period is characterized by high rates of beta cell proliferation leading to massive increases in beta cell mass. The beta cell mass expansion considerably slows down in adult animals, though variations in insulin demand due to physiological and pathological states such as pregnancy and obesity can lead to adaptive changes in the beta cells that include hyperplasia, hypertrophy, and increased insulin synthesis and secretion. Deciphering the mechanisms that regulate the plasticity of beta cell mass can be an important step in developing effective strategies to treat diabetes. |
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Authors:
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Sangeeta Dhawan; Senta Georgia; Anil Bhushan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2007-12-03 |
Journal Detail:
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Title: Current opinion in cell biology Volume: 19 ISSN: 0955-0674 ISO Abbreviation: Curr. Opin. Cell Biol. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-11 Completed Date: 2008-02-05 Revised Date: 2013-05-14 |
Medline Journal Info:
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Nlm Unique ID: 8913428 Medline TA: Curr Opin Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 634-45 Citation Subset: IM |
Affiliation:
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Larry Hillblom Islet Research Center, Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-7345, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Humans Pancreas / physiology* Regeneration* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK-068763/DK/NIDDK NIH HHS; R01 DK068763/DK/NIDDK NIH HHS; R01 DK068763-02/DK/NIDDK NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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