Document Detail

Formation of protrusions of the cell surface during tissue cell movement.
MedLine Citation:
PMID:  7192864     Owner:  NLM     Status:  MEDLINE    
The various forms of protrusions of the surface of tissue cells are described in relation to their role in cell locomotion. It is proposed that these cells have enough cell surface (plasma membrane and linked microfilamentous cortical cytoplasm) at any given moment during interphase of the cell cycle to satisfy their need for the local increases in cell surface area that accompany protrusive activity. Thus, a local increase in protrusive activity in one region of the cell surface would be accompanied by a corresponding decrease elsewhere; that is, formation of new protrusions would require retraction of other protrusions already present and the area retracted would be equivalent to the area protruded. Evidence marshaled in support of this hypothesis includes disappearance of microvilli and other microprotrusions during cell spreading, increase in protrusive activity of uncontacted regions of the cell surface during contact inhibition of cell movement, antagonism between blebbing and spreading, accelerated protrusive activity at the leading edge upon abrupt retraction of the trailing edge, surface flow during bleb formation, and antagonism between various protrusive activities associated with cell movement and cytokinesis. Finally, the relevance of these findings to two important developmental problems is explored: the commencement of gastrulation and directional cell movements during morphogenesis.
J P Trinkaus
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Progress in clinical and biological research     Volume:  41     ISSN:  0361-7742     ISO Abbreviation:  Prog. Clin. Biol. Res.     Publication Date:  1980  
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605701     Medline TA:  Prog Clin Biol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  887-906     Citation Subset:  IM    
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MeSH Terms
Cell Division
Cell Membrane / physiology*
Cell Movement*
Cells, Cultured
Cytoplasm / physiology*
Cytoskeleton / ultrastructure
Gastrula / physiology
Membrane Fluidity
Microvilli / ultrastructure
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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