Document Detail

Formation of peptide bonds from metastable versus crystalline phase: implications for the origin of life.
MedLine Citation:
PMID:  11196575     Owner:  NLM     Status:  MEDLINE    
Formation of peptide bonds was attempted by thermal activation of dry amino acids from aqueous solution that simulated prebiotic evaporative environments. The evaporation trend of amino acids solutions shows a bifurcation and can lead to either a crystalline phase (near equilibrium) or a metastable non-crystalline phase (far from equilibrium). Only amino acids in this metastable phase are able to form peptide bonds by thermal activation at temperatures that are generated by solar radiation today. We suggest that this metastable phase is the ideal initial material to trigger amino acid assemblage with protein-like structure because provide the driving force (supersaturation) for an intense interaction between monomers of different amino acids and allows activation of these monomers in plausible prebiotic conditions.
C Viedma
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life     Volume:  30     ISSN:  0169-6149     ISO Abbreviation:  Orig Life Evol Biosph     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-23     Completed Date:  2001-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610391     Medline TA:  Orig Life Evol Biosph     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  549-56     Citation Subset:  IM; S    
Departamento Cristalografia-Mineralogia, Universidad Complutense, Facultad Geologia, 28040, Madrid, Spain.
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MeSH Terms
Amino Acids / chemistry*
Evolution, Chemical*
Peptides / chemistry*
Proteins / chemistry*
Reg. No./Substance:
0/Amino Acids; 0/Peptides; 0/Proteins

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