| Formation of new vasa vasorum in vasculitis. Production of angiogenic cytokines by multinucleated giant cells. | |
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MedLine Citation:
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PMID: 10487834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammation of the arterial wall in giant cell arteritis induces a series of structural changes, including the formation of new vasa vasorum. To study the regulation of neoangiogenesis in giant cell arteritis, temporal arteries were examined for the extent and localization of microvessel generation and for the production of angiogenic factors. In normal arteries, vasa vasorum were restricted to the adventitia, but in inflamed arteries, capillaries emerged in the media and the intima. These capillaries displayed a distinct topography with a circumferential arrangement in the external one-third of the intima. Neovascularization was closely correlated with the formation of lumen-obstructing intima, the fragmentation of the internal elastic lamina, and the presence of multinucleated giant cells. Comparison of tissue cytokine transcription in temporal arteries of giant cell arteritis patients with and without up-regulated neoangiogenesis identified interferon-gamma and vascular endothelial growth factor but not fibroblast growth factor-2 as mediators associated with vasa vasorum proliferation. Giant cells and CD68-positive macrophages at the media-intima junction were found to be the major cellular sources of vascular endothelial growth factor. These data demonstrate that formation of new vasa vasorum in vasculitis is regulated by inflammatory cells and not by arterial wall cells, raising the possibility that it represents a primary disease mechanism and not a secondary hypoxia-induced event. Increased neovascularization in interferon-gamma-rich arteries suggests that the formation of new vasa vasorum is determined by the nature of the immune response in the arterial wall, possibly resulting from the generation and functional activity of multinucleated giant cells. |
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Authors:
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M Kaiser; B Younge; J Björnsson; J J Goronzy; C M Weyand |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of pathology Volume: 155 ISSN: 0002-9440 ISO Abbreviation: Am. J. Pathol. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-07 Completed Date: 1999-10-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 765-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Division of Rheumatology, Mayo Clinic and Foundation, Rochester, Minnesota, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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biosynthesis* Endothelial Growth Factors / biosynthesis Fibroblast Growth Factor 2 / biosynthesis Giant Cell Arteritis / metabolism, pathology* Giant Cells / metabolism* Humans Hyperplasia / pathology Immunohistochemistry Interferon-gamma / biosynthesis Lymphokines / biosynthesis Macrophages / metabolism Neovascularization, Pathologic / metabolism*, pathology Reverse Transcriptase Polymerase Chain Reaction Tunica Intima / metabolism, pathology Tunica Media / metabolism, pathology Vasa Vasorum / metabolism, pathology* Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY11916/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; 103107-01-3/Fibroblast Growth Factor 2; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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