Document Detail


Formation and migration of neural crest cells in the vertebrate embryo.
MedLine Citation:
PMID:  22820859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neural crest is a stem cell population, unique to vertebrates, that gives rise to a vast array of derivatives, ranging from peripheral ganglia to the facial skeleton. This population is induced in the early embryo at the border of the neural plate, which will form the central nervous system (CNS). After neural tube closure, neural crest cells depart from the dorsal CNS via an epithelial to mesenchymal transition (EMT), forming a migratory mesenchymal cell type that migrates extensive to diverse locations in the embryo. Using in vivo loss-of-function approaches and cis-regulatory analysis coupled with live imaging, we have investigated the gene regulatory network that mediates formation of this fascinating cell type. The results show that a combination of transcriptional inputs and epigenetic modifiers control the timing of onset of neural crest gene expression. This in turn leads to the EMT process that produces this migratory cell population.
Authors:
Marianne E Bronner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-22
Journal Detail:
Title:  Histochemistry and cell biology     Volume:  138     ISSN:  1432-119X     ISO Abbreviation:  Histochem. Cell Biol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-30     Completed Date:  2012-12-06     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  9506663     Medline TA:  Histochem Cell Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  179-86     Citation Subset:  IM    
Affiliation:
Division of Biology 139-74, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125, USA. mbronner@caltech.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Movement*
Epigenesis, Genetic
Epithelial-Mesenchymal Transition
Gene Regulatory Networks
Humans
Models, Biological
Neural Crest / cytology*,  metabolism
Stem Cells / cytology,  metabolism
Vertebrates / embryology
Grant Support
ID/Acronym/Agency:
HD037105/HD/NICHD NIH HHS; P01 HD037105/HD/NICHD NIH HHS; R03 DE022521/DE/NIDCR NIH HHS
Comments/Corrections

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