| Formation and maintenance of blood-urine barrier in urothelium. | |
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MedLine Citation:
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PMID: 20521071 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Blood-urine barrier, which is formed during differentiation of superficial urothelial cells, is the tightest and most impermeable barrier in the body. In the urinary bladder, the barrier must accommodate large changes in the surface area during distensions and contractions of the organ. Tight junctions and unique apical plasma membrane of superficial urothelial cells play a critical role in the barrier maintenance. Alterations in the blood-urine barrier function accompany most of the urinary tract diseases. In this review, we discuss recent discoveries on the role of tight junctions, dynamics of Golgi apparatus and post-Golgi compartments, and intracellular membrane traffic during the biogenesis and maintenance of blood-urine barrier. |
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Authors:
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Mateja Erdani Kreft; Samo Hudoklin; Kristijan Jezernik; Rok Romih |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-04 |
Journal Detail:
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Title: Protoplasma Volume: 246 ISSN: 1615-6102 ISO Abbreviation: Protoplasma Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9806853 Medline TA: Protoplasma Country: Austria |
Other Details:
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Languages: eng Pagination: 3-14 Citation Subset: IM |
Affiliation:
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Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Lipiceva 2, SI-1000, Ljubljana, Slovenia. mateja.erdani@mf.uni-lj.si |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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