| Formation of leukotrienes E3, E4 and E5 in rat basophilic leukemia cells. | |
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MedLine Citation:
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PMID: 6273168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rat basophilic leukemia (RBL-1) cells incubated with ionophore A23187 and 5,8,11-eicosatrienoic acid produced three slow-reacting substances identified as leukotrienes C3, D3 and E3 by spectroscopic, chromatographic and enzymatic methods. 5,8,11,14,17-Eicosapentaenoic acid was similarly converted by RBL-1 cells to leukotrienes C5, D5. and E5. Leukotrienes C4, D4 and E4 were also formed in these experiments from endogenous arachidonic acid. Time-course studies, incubations with 3H-labeled leukotriene C3 and effects of acivicin [L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid; a gamma-glutamyl transpeptidase inhibitor] indicated that leukotrienes C and D are intermediates in the formation of leukotrienes E. L-Cysteine enhanced the conversion of leukotriene C3 to leukotriene D3 and inhibited further degradation of leukotriene D3 to leukotriene E3. |
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Authors:
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L Orning; K Bernström; S Hammarström |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of biochemistry / FEBS Volume: 120 ISSN: 0014-2956 ISO Abbreviation: Eur. J. Biochem. Publication Date: 1981 Nov |
Date Detail:
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Created Date: 1982-02-12 Completed Date: 1982-02-12 Revised Date: 2007-07-23 |
Medline Journal Info:
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Nlm Unique ID: 0107600 Medline TA: Eur J Biochem Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 41-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8,11,14-Eicosatrienoic Acid
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pharmacology Animals Arachidonic Acid Arachidonic Acids / blood*, metabolism Basophils / metabolism* Calcimycin / pharmacology Chromatography, High Pressure Liquid Cysteine / pharmacology Glycine / analogs & derivatives, pharmacology Isoxazoles / pharmacology Leukemia, Experimental / metabolism* Leukotriene E4 Rats SRS-A / blood* |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Isoxazoles; 0/SRS-A; 2751-14-6/mead acid; 506-32-1/Arachidonic Acid; 52-90-4/Cysteine; 52583-41-2/acivicin; 52665-69-7/Calcimycin; 56-40-6/Glycine; 7324-41-6/8,11,14-Eicosatrienoic Acid; 75715-89-8/Leukotriene E4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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