Document Detail

Formation of iodoacetic acids during cooking: interaction of iodized table salt with chlorinated drinking water.
MedLine Citation:
PMID:  16982516     Owner:  NLM     Status:  MEDLINE    
Iodoacetic and chloroiodoacetic acids were formed when municipal chlorinated tap water was allowed to react with iodized (with potassium iodide) table salt or with potassium iodide itself. Iodoacetic acid was recently shown to be a potent cytotoxic and genotoxic agent. For analysis, samples were extracted with t-amyl methyl ether and converted to the corresponding methyl esters using methanol and sulfuric acid. The concentration of iodoacetic acid was determined by gas chromatography-mass spectrometry (GC-MS) using an authentic standard. The identities of iodoacetic and chloroiodoacetic acids were further confirmed by gas chromatography-high-resolution mass spectrometry (GC-HRMS). Certain influences of sodium hypochlorite and humic acid as well as the concentration of potassium iodide on the yields of these acids were investigated. The concentration of iodoacetic acid in tap water samples boiled with 2 g l-1 of iodized table salt was found to be in the 1.5 microg l-1 range, whilst the concentration of chloroiodoacetic acid was estimated to be three to five times lower.
A Becalski; B P-Y Lau; T J Schrader; S W Seaman; W F Sun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food additives and contaminants     Volume:  23     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-19     Completed Date:  2007-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  England    
Other Details:
Languages:  eng     Pagination:  957-62     Citation Subset:  IM    
Health Canada, Health Products and Food Branch, Food Research Division, Address Locator 2203D, Ottawa, Ontario K1A 0L2, Canada.
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MeSH Terms
Chlorine / chemistry*
Disinfection / methods
Gas Chromatography-Mass Spectrometry
Iodine / chemistry*
Iodoacetic Acid / analysis,  chemistry*
Sodium Chloride, Dietary
Water Pollutants, Chemical / analysis
Water Purification / methods
Water Supply / analysis*
Reg. No./Substance:
0/Sodium Chloride, Dietary; 0/Water Pollutants, Chemical; 0/iodized salt; 64-69-7/Iodoacetic Acid; 7553-56-2/Iodine; 7782-50-5/Chlorine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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