| Formation of hemoglobin adducts of acrylamide after its ingestion in rats is dependent on age and sex. | |
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MedLine Citation:
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PMID: 18540624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of fiber and fat contents of food and of age and sex of animals on the formation of hemoglobin adducts of acrylamide (AA-Hb) in blood has been studied. The results suggest that the absorption of acrylamide (AA) present in food is not affected by the fiber or fat contents of food. However, AA-Hb resulting from the intake of an aqueous solution of AA is dependent on the age and sex of rats: AA-Hb levels were higher in females than in males (3.53- and 2.55-fold higher, respectively, for AA doses of 25 and 100 mg/kg) and in younger than in older rats (30.1% higher in 1.5 month old as compared to 14 month old rats). In males, AA-Hb levels found after the oral administration of AA in an aqueous solution were significantly lower than those found after dietary or intravenous administration. In conclusion, these results show the existence of significant differences in AA bioavailability from an aqueous solution depending on the sex and age of animals. If similar differences also occur in humans, they would be relevant to assess the exposure of different subpopulations to AA. |
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Authors:
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Juana Sánchez; Joana M Cabrer; Catalina A Rosselló; Andreu Palou; Catalina Picó |
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Publication Detail:
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Type: Journal Article Date: 2008-06-10 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 56 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-03 Completed Date: 2008-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 5096-101 Citation Subset: IM |
Affiliation:
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University of the Balearic Islands (UIB), Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), Cra. Valldemossa Km 7.5, Palma de Mallorca-07122, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylamide
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blood,
pharmacokinetics,
toxicity* Age Factors Animals Biological Availability Carcinogens / pharmacokinetics, toxicity* Dietary Fiber / analysis Eating Fats / analysis Female Food Analysis* Hemoglobins / chemistry* Male Rats Rats, Wistar Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Fats; 0/Hemoglobins; 79-06-1/Acrylamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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