Document Detail


Formation of hemoglobin adducts of acrylamide after its ingestion in rats is dependent on age and sex.
MedLine Citation:
PMID:  18540624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of fiber and fat contents of food and of age and sex of animals on the formation of hemoglobin adducts of acrylamide (AA-Hb) in blood has been studied. The results suggest that the absorption of acrylamide (AA) present in food is not affected by the fiber or fat contents of food. However, AA-Hb resulting from the intake of an aqueous solution of AA is dependent on the age and sex of rats: AA-Hb levels were higher in females than in males (3.53- and 2.55-fold higher, respectively, for AA doses of 25 and 100 mg/kg) and in younger than in older rats (30.1% higher in 1.5 month old as compared to 14 month old rats). In males, AA-Hb levels found after the oral administration of AA in an aqueous solution were significantly lower than those found after dietary or intravenous administration. In conclusion, these results show the existence of significant differences in AA bioavailability from an aqueous solution depending on the sex and age of animals. If similar differences also occur in humans, they would be relevant to assess the exposure of different subpopulations to AA.
Authors:
Juana Sánchez; Joana M Cabrer; Catalina A Rosselló; Andreu Palou; Catalina Picó
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Publication Detail:
Type:  Journal Article     Date:  2008-06-10
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-03     Completed Date:  2008-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5096-101     Citation Subset:  IM    
Affiliation:
University of the Balearic Islands (UIB), Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), Cra. Valldemossa Km 7.5, Palma de Mallorca-07122, Spain.
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MeSH Terms
Descriptor/Qualifier:
Acrylamide / blood,  pharmacokinetics,  toxicity*
Age Factors
Animals
Biological Availability
Carcinogens / pharmacokinetics,  toxicity*
Dietary Fiber / analysis
Eating
Fats / analysis
Female
Food Analysis*
Hemoglobins / chemistry*
Male
Rats
Rats, Wistar
Sex Factors
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Fats; 0/Hemoglobins; 79-06-1/Acrylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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