| Formation and functions of asymmetric microtubule organization in polarized cells. | |
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MedLine Citation:
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PMID: 22704717 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Although microtubules are known to be essential for chromosome segregation during cell division, they also play important roles in the regulation and function of cell polarity. Cell polarization is fundamental to appropriate tissue patterning and the regulation of cellular diversity during animal development. In polarized cells, microtubules are often organized asymmetrically along the polarity axis. Recent studies show that such asymmetry in microtubule organization is important to connect a cell's polarization with its polarized functions. In some cases, asymmetrically organized microtubule arrays themselves induce cell polarity. Here we present an overview of the mechanisms and functions of asymmetric microtubule organization and discuss the possible role of microtubule asymmetry in the symmetry-breaking that leads to cell polarization. |
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Authors:
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Kenji Sugioka; Hitoshi Sawa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-14 |
Journal Detail:
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Title: Current opinion in cell biology Volume: - ISSN: 1879-0410 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913428 Medline TA: Curr Opin Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Multicellular Organization Laboratory, National Institute of Genetics, 1111 Yata, Mishima 411-8540, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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