Document Detail


Formation and functions of asymmetric microtubule organization in polarized cells.
MedLine Citation:
PMID:  22704717     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although microtubules are known to be essential for chromosome segregation during cell division, they also play important roles in the regulation and function of cell polarity. Cell polarization is fundamental to appropriate tissue patterning and the regulation of cellular diversity during animal development. In polarized cells, microtubules are often organized asymmetrically along the polarity axis. Recent studies show that such asymmetry in microtubule organization is important to connect a cell's polarization with its polarized functions. In some cases, asymmetrically organized microtubule arrays themselves induce cell polarity. Here we present an overview of the mechanisms and functions of asymmetric microtubule organization and discuss the possible role of microtubule asymmetry in the symmetry-breaking that leads to cell polarization.
Authors:
Kenji Sugioka; Hitoshi Sawa
Related Documents :
16467357 - Determination of cell fate along the anteroposterior axis of the drosophila ventral mid...
14527717 - Identification of the drosophila progenitor of mammalian krüppel-like factors 6 and 7 ...
16760977 - Social interactions among epithelial cells during tracheal branching morphogenesis.
9232597 - Combinatorial signaling by twisted gastrulation and decapentaplegic.
8732337 - 'undifferentiated progenitor cells' in focal nodular hyperplasia of the liver.
24530397 - Reciprocal effects between microrna-140-5p and adam10 suppress migration and invasion o...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-14
Journal Detail:
Title:  Current opinion in cell biology     Volume:  -     ISSN:  1879-0410     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Multicellular Organization Laboratory, National Institute of Genetics, 1111 Yata, Mishima 411-8540, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The placebo arm in clinical studies for treatment of Psychiatric Disorders: A Regulatory Dilemma.
Next Document:  Array CGH improves detection of mutations in the GALC gene associated with Krabbe disease.