Document Detail

Formation of a diazoquinone-type mutagen from acetaminophen treated with nitrite under acidic conditions.
MedLine Citation:
PMID:  3057376     Owner:  NLM     Status:  MEDLINE    
Acetaminophen (paracetamol) showed mutagenicity to Salmonella typhimurium TA100 and TA98 either with or without S9 mix when treated with excess nitrite in acidic solution. The mutagen was isolated and identified as 4-acetylamino-6-diazo-2,4-cyclohexadienone. Mutation tests and product analysis by high-performance liquid chromatography, however, suggested that this type of mutagen was hardly formed in the digestive tract of normal subjects.
T Ohta; H Oribe; T Kameyama; Y Goto; S Takitani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  209     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:    1988 Nov-Dec
Date Detail:
Created Date:  1989-01-06     Completed Date:  1989-01-06     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
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MeSH Terms
Acetaminophen / metabolism*,  pharmacology
Chromatography, High Pressure Liquid
Nitrites / pharmacology*
Salmonella typhimurium / drug effects
Reg. No./Substance:
0/Mutagens; 0/Nitrites; 103-90-2/Acetaminophen

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