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Formation, conversion, and utilization of isorhodopsin, rhodopsin, and porphyropsin by rod photoreceptors in the Xenopus retina.
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MedLine Citation:
PMID:  731199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The visual pigment content of rod photoreceptors in Xenopus larvae was reduced greater than 90% through a combination of vitamin A-deficient diet and constant light. Thereafter, a dose of either all-trans-retinol or 9-cis-retinal was injected intramuscularly, leading to the formation of a rhodopsin (lambdamax 504 nm) or isorhodopsin (lambdamax 487-493 nm) pigment, respectively. Electrophysiological measurements were made of the threshold and spectral sensitivity of the aspartate-isolated PIII (photoreceptoral) component of the electroretinogram. These measures established that either rhodopsin or isorhodopsin subserved visual transduction with the same efficiency as the 519 nm porphyropsin pigment encountered normally. When animals with rhodopsin or isorhodopsin were kept in darkness or placed on a cyclical lighting regimen for 8 days, retinal densitometry showed that either pigment was being converted to porphyropsin; significantly more porphyropsin was formed as a result of cyclical lighting than after complete darkness.
Authors:
P Witkovsky; G A Engbretson; H Ripps
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of general physiology     Volume:  72     ISSN:  0022-1295     ISO Abbreviation:  J. Gen. Physiol.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985110R     Medline TA:  J Gen Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  821-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Darkness
Electrophysiology
Light
Photoreceptor Cells / metabolism*,  physiology
Retinal Pigments / metabolism*
Retinaldehyde / metabolism
Rhodopsin / metabolism*
Vitamin A / metabolism
Xenopus
Chemical
Reg. No./Substance:
0/Retinal Pigments; 11103-57-4/Vitamin A; 116-31-4/Retinaldehyde; 9009-81-8/Rhodopsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Gen Physiol
ISSN: 0022-1295
ISSN: 1540-7748
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 12 Year: 1978
Volume: 72 Issue: 6
First Page: 821 Last Page: 836
ID: 2228495
Publisher Id: 79090079
PubMed Id: 731199

Formation, conversion, and utilization of isorhodopsin, rhodopsin, and porphyropsin by rod photoreceptors in the Xenopus retina


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