| Formation of calcium deficient HAp/collagen composites by hydrolysis of alpha-TCP. | |
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MedLine Citation:
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PMID: 20652375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone-like composites containing calcium deficient hydroxyapatite (CDHAp) were formed by the hydrolysis of alpha-tricalcium phosphate (alpha-TCP) in the presence of type I collagen. CDHAp-collagen composites were synthesized using two techniques. In one technique alpha-TCP was mixed with non-milled (as-received) collagen prior to the addition of the aqueous solution. In the second, the collagen was milled with alpha-TCP in heptane at room temperature prior to its conversion to CDHAp. The effect of milling strongly facilitates the formation of CDHAp at physiological temperature. The proportion of milled collagen between 5 and 20 wt% present in the alpha-TCP/collagen composites has no significant effect on the rate of CDHAp formation. Variations in pH and in calcium and phosphate concentrations were determined as a function of collagen processing and variations specific to the presence of collagen were discerned. Compared to CDHAp or to composites containing non-milled collagen, diametrical and compressive strengths of CDHAp increased in the presence of milled collagen. Lack of collagen dispersion and incomplete formation of CDHAp during 48 h were the bases for reduced strengths of composites containing non-milled collagen. |
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Authors:
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Ahmed H Touny; Sarit Bhaduri; Paul W Brown |
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Publication Detail:
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Type: Journal Article Date: 2010-07-22 |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 21 ISSN: 1573-4838 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 2533-41 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, University of Toledo, Toledo, OH 43606, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calcium
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chemistry* Calcium Phosphates / chemistry* Collagen / chemistry* Hydrogen-Ion Concentration Hydrolysis |
| Chemical | |
Reg. No./Substance:
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0/Calcium Phosphates; 0/alpha-tricalcium phosphate; 7440-70-2/Calcium; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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