| Formation of apatite on poly(alpha-hydroxy acid) in an accelerated biomimetic process. | |
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MedLine Citation:
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PMID: 15672402 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bonelike apatite coating was formed on poly(L-lactic acid) films and poly(glycolic acid) scaffolds within 24 h through an accelerated biomimetic process. The ion concentrations in the simulated body fluid (SBF) were nearly 5 times of those in the human blood plasma. The apatite formed was characterized by using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The apatite formed in 5SBFs was similar in morphology and composition to that formed in the classical biomimetic process using SBF or 1.5SBF and similar to that of natural bone. This indicated that the biomimetic apatite-coating process could be accelerated by using concentrated simulated body fluid at 37 degrees C. Besides saving time, the accelerated biomimetic process is particularly significant to biodegradable polymers. Some polymers that degrade too fast to be coated with apatite by a classical biomimetic process (e.g., PGA) could be coated with bonelike apatite in an accelerated biomimetic process. |
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Authors:
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Yun Chen; Arthur F T Mak; Jiashen Li; Min Wang; Anita W T Shum |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical materials research. Part B, Applied biomaterials Volume: 73 ISSN: 1552-4973 ISO Abbreviation: J. Biomed. Mater. Res. Part B Appl. Biomater. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-28 Completed Date: 2005-07-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101234238 Medline TA: J Biomed Mater Res B Appl Biomater Country: United States |
Other Details:
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Languages: eng Pagination: 68-76 Citation Subset: IM |
Copyright Information:
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(c) 2005 Wiley Periodicals, Inc. |
Affiliation:
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Jockey Club Rehabilitation Engineering Center, The Hong Kong Polytechnic University, Hong Hum, Kowloon, Hong Kong, China. rcafmak@polyu.edu.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apatites
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chemistry* Biocompatible Materials / chemistry* Biomimetics Bone Substitutes / chemistry* Bone and Bones / metabolism Humans Hydrogen-Ion Concentration Ions Lactic Acid / chemistry* Microscopy, Electron, Scanning Models, Chemical Polyglycolic Acid / chemistry* Polymers / chemistry* Solubility Spectrometry, X-Ray Emission Spectroscopy, Fourier Transform Infrared Surface Properties Temperature Time Factors X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
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0/Apatites; 0/Biocompatible Materials; 0/Bone Substitutes; 0/Ions; 0/Polymers; 26009-03-0/Polyglycolic Acid; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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