Document Detail

Formation and action of prostaglandin endoperoxides in the isolated human umbilical artery.
MedLine Citation:
PMID:  1258667     Owner:  NLM     Status:  MEDLINE    
The effects on the isolated human umbilical artery (HUA) of the recently isolated endoperoxide intermediates in prostaglandin (PG) biosynthesis, PGG2 and PGH2, were studied. Both endoperoxides were potent contractors of the artery strips, the threshold concentrations being 3 (1-4) ng/ml for PGG2 and 1 (1-12) ng/ml for PGH2, as compared with 200 (40-400) ng/ml for PGE2. The hemiacetal derivative of 8-(1-hydroxy-3-oxopropyl)-9,12L-dihydroxy-5,10-heptadecadienoic acid (thromboxane B2), a metabolite of PGG2, appeared in the bath medium indicating PG and thromboxane generation in the isolated HUA. The formation of thromboxane B2 was inhibited by indomethacin (8-40 mug/ml) and by eicosa-5,8,11,14-tetraynoic acid (ETA) (25 mug/ml), ETA also inhibited the contractile responses to both endoperoxides. The results support the view that local generation of PGs might be involved in the closure of the HUA at birth.
T Tuvemo; K Strandberg; M Hamberg; B Samuelsson
Related Documents :
1993487 - Acid-induced increase in electrical conductance of guinea pig duodenal mucosa in vitro....
3247467 - In vitro inhibition of prostaglandin production by azathioprine and 6-mercaptopurine.
8373167 - Oxygenation of 5,8,11-eicosatrienoic acid by prostaglandin endoperoxide synthase and by...
6957237 - The effect of systemic prednisolone on arachidonic acid, and prostaglandin e2 and f2 al...
1032067 - Gastric acid secretion in patients with prepyloric ulcer and with combined gastric and ...
8050997 - Identification of amino acid residues in streptococcus mutans glucosyltransferases infl...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  96     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-05-20     Completed Date:  1976-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  145-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
5,8,11,14-Eicosatetraynoic Acid / pharmacology
Arteries / drug effects*
Indomethacin / pharmacology
Muscle, Smooth / drug effects*
Peroxides* / biosynthesis,  metabolism,  pharmacology
Prostaglandins / biosynthesis*,  pharmacology
Prostaglandins E / biosynthesis
Umbilical Arteries / metabolism*
Reg. No./Substance:
0/Peroxides; 0/Prostaglandins; 0/Prostaglandins E; 1191-85-1/5,8,11,14-Eicosatetraynoic Acid; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sex differences in renal damage induced in the rat by the Finnish mushroom, Cortinarius speciosissim...
Next Document:  A method for preparing isolated glands from the rabbit gastric mucosa.