Document Detail


Formation and action of prostaglandin endoperoxides in the isolated human umbilical artery.
MedLine Citation:
PMID:  1258667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects on the isolated human umbilical artery (HUA) of the recently isolated endoperoxide intermediates in prostaglandin (PG) biosynthesis, PGG2 and PGH2, were studied. Both endoperoxides were potent contractors of the artery strips, the threshold concentrations being 3 (1-4) ng/ml for PGG2 and 1 (1-12) ng/ml for PGH2, as compared with 200 (40-400) ng/ml for PGE2. The hemiacetal derivative of 8-(1-hydroxy-3-oxopropyl)-9,12L-dihydroxy-5,10-heptadecadienoic acid (thromboxane B2), a metabolite of PGG2, appeared in the bath medium indicating PG and thromboxane generation in the isolated HUA. The formation of thromboxane B2 was inhibited by indomethacin (8-40 mug/ml) and by eicosa-5,8,11,14-tetraynoic acid (ETA) (25 mug/ml), ETA also inhibited the contractile responses to both endoperoxides. The results support the view that local generation of PGs might be involved in the closure of the HUA at birth.
Authors:
T Tuvemo; K Strandberg; M Hamberg; B Samuelsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  96     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-05-20     Completed Date:  1976-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  145-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
5,8,11,14-Eicosatetraynoic Acid / pharmacology
Arteries / drug effects*
Humans
Indomethacin / pharmacology
Male
Muscle, Smooth / drug effects*
Peroxides* / biosynthesis,  metabolism,  pharmacology
Prostaglandins / biosynthesis*,  pharmacology
Prostaglandins E / biosynthesis
Umbilical Arteries / metabolism*
Chemical
Reg. No./Substance:
0/Peroxides; 0/Prostaglandins; 0/Prostaglandins E; 1191-85-1/5,8,11,14-Eicosatetraynoic Acid; 53-86-1/Indomethacin

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