| Formation and action of prostaglandin endoperoxides in the isolated human umbilical artery. | |
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MedLine Citation:
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PMID: 1258667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects on the isolated human umbilical artery (HUA) of the recently isolated endoperoxide intermediates in prostaglandin (PG) biosynthesis, PGG2 and PGH2, were studied. Both endoperoxides were potent contractors of the artery strips, the threshold concentrations being 3 (1-4) ng/ml for PGG2 and 1 (1-12) ng/ml for PGH2, as compared with 200 (40-400) ng/ml for PGE2. The hemiacetal derivative of 8-(1-hydroxy-3-oxopropyl)-9,12L-dihydroxy-5,10-heptadecadienoic acid (thromboxane B2), a metabolite of PGG2, appeared in the bath medium indicating PG and thromboxane generation in the isolated HUA. The formation of thromboxane B2 was inhibited by indomethacin (8-40 mug/ml) and by eicosa-5,8,11,14-tetraynoic acid (ETA) (25 mug/ml), ETA also inhibited the contractile responses to both endoperoxides. The results support the view that local generation of PGs might be involved in the closure of the HUA at birth. |
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Authors:
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T Tuvemo; K Strandberg; M Hamberg; B Samuelsson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 96 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1976 Feb |
Date Detail:
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Created Date: 1976-05-20 Completed Date: 1976-05-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 145-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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5,8,11,14-Eicosatetraynoic Acid
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pharmacology Arteries / drug effects* Humans Indomethacin / pharmacology Male Muscle, Smooth / drug effects* Peroxides* / biosynthesis, metabolism, pharmacology Prostaglandins / biosynthesis*, pharmacology Prostaglandins E / biosynthesis Umbilical Arteries / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Peroxides; 0/Prostaglandins; 0/Prostaglandins E; 1191-85-1/5,8,11,14-Eicosatetraynoic Acid; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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