Document Detail

Formation of acetylcarnitine in muscle of horse during high intensity exercise.
MedLine Citation:
PMID:  3678216     Owner:  NLM     Status:  MEDLINE    
To study the changes in carnitine in muscle with spring exercise, two Thoroughbred horses performed two treadmill exercise tests. Biopsies of the middle gluteal were taken before, after exercise and after 12 min recovery. Resting mean muscle total carnitine content was 29.5 dry muscle (d.m.). Approximately 88% was free carnitine, 7% acetylcarnitine and acylcarnitine was estimated at 5%. Exercise did not affect total carnitine, but resulted in a marked fall in free carnitine and almost equivalent rise in acetylcarnitine. The results are consistent with a role for carnitine in the regulation of the acetyl-CoA/CoA ratio during sprint exercise in the Thoroughbred horse by buffering excess production of acetyl units.
C V Foster; R C Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  56     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-12     Completed Date:  1988-01-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  639-42     Citation Subset:  IM; S    
Physiology Unit, Animal Health Trust, Suffolk, England.
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MeSH Terms
Acetylcarnitine / metabolism*
Carbohydrate Metabolism
Carnitine / analogs & derivatives*
Glycerol / blood
Glycerophosphates / blood
Horses / metabolism
Lactates / blood
Muscles / metabolism*
Physical Exertion*
Reg. No./Substance:
0/Glycerophosphates; 0/Lactates; 14992-62-2/Acetylcarnitine; 541-15-1/Carnitine; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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