Document Detail


Formation of the ovarian follicular antrum and follicular fluid.
MedLine Citation:
PMID:  20164441     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The formation of the follicular antrum and follicular fluid has received scant attention from researchers, yet both are important processes in follicular development. The central hypothesis on follicular fluid formation suggests that production by granulosa cells of hyaluronan and the chondroitin sulfate proteoglycan versican generates an osmotic gradient. This gradient draws in fluid derived from the thecal vasculature. Inter-alpha-trypsin inhibitor is also present in follicular fluid at least in species with large follicles, and inter-alpha-trypsin inhibitor and versican could additionally bind or cross-link with hyaluronan, resulting in the retention of these molecules within the follicular antrum. Barriers to the movement of fluid across the membrana granulosa are apparently minimal, as even relatively large serum proteins are present in follicular fluid. Despite the relative permeability of the follicular wall, aquaporins are present in granulosa cells and could be actively involved in the transport of water into the follicle. The formation of an antrum also requires movement of granulosa cells relative to each other to allow the fluid to accumulate. This presumably involves remodeling of cell-cell junctions and in species with small follicles may involve death of centrally located granulosa cells. Remodeling of the stroma and thecal layers also accompanies growth and expansion of the antrum and presumably involves similar processes that accompany growth of other glands.
Authors:
Raymond J Rodgers; Helen F Irving-Rodgers
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-02-17
Journal Detail:
Title:  Biology of reproduction     Volume:  82     ISSN:  1529-7268     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1021-9     Citation Subset:  IM    
Affiliation:
Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Institute, The University of Adelaide, Adelaide, South Australia, Australia. ray.rodgers@adelaide.edu.au
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MeSH Terms
Descriptor/Qualifier:
Alpha-Globulins / metabolism
Animals
Aquaporins / analysis
Cattle
Cell Movement
Cricetinae
Female
Follicular Fluid / physiology*
Granulosa Cells / metabolism,  physiology*
Humans
Hyaluronic Acid / biosynthesis
Mice
Oocytes / metabolism
Osmosis / physiology
Ovarian Follicle / physiology*
Proteochondroitin Sulfates / biosynthesis
Rats
Versicans / biosynthesis
Chemical
Reg. No./Substance:
0/Alpha-Globulins; 0/Aquaporins; 0/Proteochondroitin Sulfates; 126968-45-4/Versicans; 39346-44-6/inter-alpha-inhibitor; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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