Document Detail


Formation and Characterization of Reversed Micelles Composed of Phospholipids and Fatty Acids.
MedLine Citation:
PMID:  11482967     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The formation of reversed micellar systems composed of phosphatidylcholine (PC) and fatty acid was newly demonstrated by a significant increase in water content in the organic ethyl oleate phase when the micelles were prepared by the contact method. The solubilized water concentration in the reversed micellar organic phase reached 3 wt%. The new systems are expected to be used as highly biocompatible reversed micellar systems. The structure of the reversed micelles composed of PC and oleic acid was characterized by determining the water concentration and by small-angle X-ray scattering analysis. The reversed micelles composed of PC and oleic acid formed in ethyl oleate were spherical. The radius of gyration was between 30 and 50 Å. The size of the reversed micelles decreased with an increase in the oleic acid concentration and was independent of the PC concentration. Experimental results indicated that the structure of the reversed micellar system was determined by the oleic acid concentration. An increase in the PC concentration caused an increase in the number of reversed micelles of the same size. These reversed micellar systems are expected to be used as solubilization media in pharmaceutical and food industries because they are not toxic. Copyright 2001 Academic Press.
Authors:
Shinji Sugiura; Sosaku Ichikawa; Yoh Sano; Mitsutoshi Nakajima; Xin Qi Liu; Minoru Seki; Shintaro Furusaki
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of colloid and interface science     Volume:  240     ISSN:  1095-7103     ISO Abbreviation:  J Colloid Interface Sci     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-Aug-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043125     Medline TA:  J Colloid Interface Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  566-572     Citation Subset:  -    
Affiliation:
Department of Chemistry and Biotechnology, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8656, Japan
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