Document Detail

Formate concentrations in plasma from patients poisoned with methanol.
MedLine Citation:
PMID:  6837328     Owner:  NLM     Status:  MEDLINE    
Formate and methanol were quantified in blood samples from 11 untreated methanol-poisoned subjects. The range for whole blood methanol concentrations was 0-137 mmol/l and for plasma formate concentrations 0.4-17.1 mmol/l. Simultaneously determined acid-base status and serum electrolyte concentrations allowed assessment of the relative importance of formate accumulation for the acidosis. The plasma formate concentration was highly correlated to both the calculated anion gap (r = 0.833), the bicarbonate concentration (r = 0.852) and the negative base excess (r = 0.865). The accumulation of formate fully accounted for the increase in the anion gap and the fall in plasma bicarbonate, whereas the negative base excess values were about 22% higher than the plasma formate concentration. We conclude that formate accumulation is the main or only reason for acidosis in the early, uncomplicated stages of methanol poisoning. Lactate may appear at more advanced stages.
O M Sejersted; D Jacobsen; S Ovrebø; H Jansen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  213     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1983  
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
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MeSH Terms
Acid-Base Imbalance / etiology
Electrolytes / blood
Formates / blood*
Methanol / blood,  poisoning*
Reg. No./Substance:
0/Electrolytes; 0/Formates; 67-56-1/Methanol

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