Document Detail

Formalin: nephrotoxic teratogen?
MedLine Citation:
PMID:  21040205     Owner:  NLM     Status:  MEDLINE    
Formaldehyde is an extensively used chemical; its ill effects have been of concern. Its nephrotoxic effects in laboratory animals and carcinogenic effects on humans are well established. We report of a pregnant woman with a normal ongoing pregnancy with a morphologically normal fetus. She was exposed to high doses of formaldehyde through inhalational route in the second trimester. Six weeks later she was found to have severe oligohydramnios with dysplastic fetal kidneys and fetal ascites. The various known causes for this problem reported in the literature are discussed. Based on the discussion the author has drawn a conclusion that the fate of the fetus reported can be attributed to transplacental nephrotoxic effect of formaldehyde. Previously two cases of malformations have been reported but this appears to be the first case of transplacental nephrotoxicty of formaldehyde.
Gowri Dorairajan
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-10-11
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  36     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-30     Completed Date:  2011-03-30     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1256-60     Citation Subset:  IM    
Copyright Information:
© 2010 The Author. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology.
Department of Obstetrics and Gynaecology, Sri Lakshmi Narayana Institute of Medical Sciences, Osudu, Agaram Village, Puducherry, India.
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MeSH Terms
Fatal Outcome
Fixatives / poisoning*
Formaldehyde / poisoning*
Infant, Newborn
Kidney / abnormalities*,  drug effects
Oligohydramnios / chemically induced*
Ultrasonography, Prenatal
Reg. No./Substance:
0/Fixatives; 50-00-0/Formaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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