Document Detail

Formalin-induced c-fos expression in the brain of infant rats.
MedLine Citation:
PMID:  21146467     Owner:  NLM     Status:  MEDLINE    
PERSPECTIVE: Because the infant processes pain differently than the adult, knowledge of those differences informs pediatric clinical practice. Using Fos expression as a marker of neural activity in the rat, we show that the pattern of brain activation is immature at birth but is in place by 14 days of age.
Gordon A Barr
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-12-13
Journal Detail:
Title:  The journal of pain : official journal of the American Pain Society     Volume:  12     ISSN:  1528-8447     ISO Abbreviation:  J Pain     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-04     Completed Date:  2012-01-09     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  100898657     Medline TA:  J Pain     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Pain Society. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Animals, Newborn
Biological Markers / metabolism
Brain / embryology,  growth & development*,  metabolism*
Gene Expression Regulation, Developmental*
Pain / metabolism*
Pain Measurement / methods*
Proto-Oncogene Proteins c-fos / biosynthesis*,  genetics,  metabolism
Rats, Long-Evans
Grant Support
DA000325/DA/NIDA NIH HHS; DA007341/DA/NIDA NIH HHS; K02 DA000325/DA/NIDA NIH HHS; K02 DA000325-10/DA/NIDA NIH HHS; R01 DA007341/DA/NIDA NIH HHS; R01 DA007341-01A1/DA/NIDA NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Proto-Oncogene Proteins c-fos

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