| Formaldehyde suppresses neuronal apoptosis via inhibition of outward K(+) currents in rat hippocampus. | |
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MedLine Citation:
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PMID: 22040012 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Formaldehyde (FA) is widely present in the environment, and is also a mammalian metabolite. However, its biological role has not been well understood. Here, we show that FA plays an anti-apoptotic role in cultured hippocampal neurons: FA suppressed staurosporine-induced neuronal apoptosis and inhibited the activity of apoptosis-associated caspase-3/7 proteases in a concentration-dependent manner. Moreover, FA suppressed outward K(+) currents and attenuated the enhanced I(K) currents that are associated with neuronal apoptosis. As an increase in outward K(+) currents is critical for cell apoptosis, our results suggest that FA exerts its anti-apoptotic effects on neuronal cells, probably through its inhibitory effect on the outward K(+) currents. |
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Authors:
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Pei Liu; Jianli Guo; Zhi Qi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-1 |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: - ISSN: 1205-7541 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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a State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, 15 Datun Road, Beijing 100101, China. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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