| Formal Synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol From D-(+)-Arabitol. | |
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MedLine Citation:
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PMID: 23049145 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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2-C-methyl-D-erythritol-4-phosphate (MEP) is a key chemical intermediate of the non-mevalonate pathway for isoprenoid biosynthesis employed by many pathogenic microbes. MEP is also the precursor for the synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol (CDP-ME), another key intermediate of the non-mevalonate pathway. As this pathway is non-existent in higher animals, including humans, it represents great opportunities for novel antimicrobial development. To facilitate the in-depth studies of this pathway, we reported here a formal synthesis of CDP-ME through a new synthesis of 2-C-Methyl-D-erythritol-4-phosphoric acid from D-(+)-arabitol. |
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Authors:
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Sina I Odejinmi; Rafael G Rascon; Wyman Chen; Kent Lai |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Tetrahedron Volume: 68 ISSN: 0040-4020 ISO Abbreviation: Tetrahedron Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984170R Medline TA: Tetrahedron Country: - |
Other Details:
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Languages: ENG Pagination: 8937-8941 Citation Subset: - |
Affiliation:
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Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84132, U.S.A. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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